Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine

Lily Arrue, Lars Ratjen

Resultado de la investigación: Review article

3 Citas (Scopus)

Resumen

The photochemical control of structure and reactivity bears great potential for chemistry, biology, and life sciences. A key feature of photochemistry is the spatiotemporal control over secondary events. Well-established applications of photochemistry in medicine are photodynamic therapy (PDT) and photopharmacology (PP). However, although both are highly localizable through the application of light, they lack cell- and tissue-specificity. The combination of nanomaterial-based drug delivery and targeting has the potential to overcome limitations for many established therapy concepts. Even more privileged seems the merger of nanomedicine and cell-specific targeting (internal targeting) controlled by light (external control), as it can potentially be applied to many different areas of medicine and pharmaceutical research, including the aforementioned PDT and PP. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine.

Idioma originalEnglish
Páginas (desde-hasta)1908-1916
Número de páginas9
PublicaciónChemMedChem
Volumen12
N.º23
DOI
EstadoPublished - 7 dic 2017
Publicado de forma externa

Huella dactilar

Nanomedicine
Medical nanotechnology
Photochemistry
Internal-External Control
Photochemical reactions
Medicine
Photodynamic therapy
Photochemotherapy
Light
Organ Specificity
Biological Science Disciplines
Nanostructures
Drug Delivery Systems
Drug delivery
Nanostructured materials
Tissue
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Citar esto

Arrue, Lily ; Ratjen, Lars. / Internal Targeting and External Control : Phototriggered Targeting in Nanomedicine. En: ChemMedChem. 2017 ; Vol. 12, N.º 23. pp. 1908-1916.
@article{a187bfc1f15d4f7698c8acac93838b99,
title = "Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine",
abstract = "The photochemical control of structure and reactivity bears great potential for chemistry, biology, and life sciences. A key feature of photochemistry is the spatiotemporal control over secondary events. Well-established applications of photochemistry in medicine are photodynamic therapy (PDT) and photopharmacology (PP). However, although both are highly localizable through the application of light, they lack cell- and tissue-specificity. The combination of nanomaterial-based drug delivery and targeting has the potential to overcome limitations for many established therapy concepts. Even more privileged seems the merger of nanomedicine and cell-specific targeting (internal targeting) controlled by light (external control), as it can potentially be applied to many different areas of medicine and pharmaceutical research, including the aforementioned PDT and PP. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine.",
keywords = "drug delivery, nanomedicine, nanotechnology, photochemistry, targeting",
author = "Lily Arrue and Lars Ratjen",
year = "2017",
month = "12",
day = "7",
doi = "10.1002/cmdc.201700621",
language = "English",
volume = "12",
pages = "1908--1916",
journal = "ChemMedChem",
issn = "1860-7179",
publisher = "John Wiley and Sons Ltd",
number = "23",

}

Internal Targeting and External Control : Phototriggered Targeting in Nanomedicine. / Arrue, Lily; Ratjen, Lars.

En: ChemMedChem, Vol. 12, N.º 23, 07.12.2017, p. 1908-1916.

Resultado de la investigación: Review article

TY - JOUR

T1 - Internal Targeting and External Control

T2 - Phototriggered Targeting in Nanomedicine

AU - Arrue, Lily

AU - Ratjen, Lars

PY - 2017/12/7

Y1 - 2017/12/7

N2 - The photochemical control of structure and reactivity bears great potential for chemistry, biology, and life sciences. A key feature of photochemistry is the spatiotemporal control over secondary events. Well-established applications of photochemistry in medicine are photodynamic therapy (PDT) and photopharmacology (PP). However, although both are highly localizable through the application of light, they lack cell- and tissue-specificity. The combination of nanomaterial-based drug delivery and targeting has the potential to overcome limitations for many established therapy concepts. Even more privileged seems the merger of nanomedicine and cell-specific targeting (internal targeting) controlled by light (external control), as it can potentially be applied to many different areas of medicine and pharmaceutical research, including the aforementioned PDT and PP. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine.

AB - The photochemical control of structure and reactivity bears great potential for chemistry, biology, and life sciences. A key feature of photochemistry is the spatiotemporal control over secondary events. Well-established applications of photochemistry in medicine are photodynamic therapy (PDT) and photopharmacology (PP). However, although both are highly localizable through the application of light, they lack cell- and tissue-specificity. The combination of nanomaterial-based drug delivery and targeting has the potential to overcome limitations for many established therapy concepts. Even more privileged seems the merger of nanomedicine and cell-specific targeting (internal targeting) controlled by light (external control), as it can potentially be applied to many different areas of medicine and pharmaceutical research, including the aforementioned PDT and PP. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine.

KW - drug delivery

KW - nanomedicine

KW - nanotechnology

KW - photochemistry

KW - targeting

UR - http://www.scopus.com/inward/record.url?scp=85037711869&partnerID=8YFLogxK

U2 - 10.1002/cmdc.201700621

DO - 10.1002/cmdc.201700621

M3 - Review article

C2 - 29073328

AN - SCOPUS:85037711869

VL - 12

SP - 1908

EP - 1916

JO - ChemMedChem

JF - ChemMedChem

SN - 1860-7179

IS - 23

ER -