Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae

Hernán F. Peñaloza, Pamela A. Nieto, Natalia Muñoz-Durango, Francisco J. Salazar-Echegarai, Javiera Torres, María J. Parga, Manuel Alvarez-Lobos, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno

Resultado de la investigación: Article

35 Citas (Scopus)

Resumen

Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well as otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation of lungs due to S. pneumoniae infection promotes bacterial dissemination and severe disease. However, the contribution of anti-inflammatory molecules to the pathogenesis of S. pneumoniae remains unknown. To elucidate whether the production of the anti-inflammatory cytokine interleukin-10 (IL-10) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed S. pneumoniae infections in mice lacking IL-10 (IL-10-/- mice). The IL-10-/- mice showed increased mortality, higher expression of pro-inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after S. pneumoniae infection. However, IL-10-/- mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL-10 during S. pneumoniae infection modulates the expression of pro-inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL-10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.

Idioma originalEnglish
Páginas (desde-hasta)100-112
Número de páginas13
PublicaciónImmunology
Volumen146
N.º1
DOI
EstadoPublished - 1 sep 2015

Huella dactilar

Pneumococcal Infections
Neutrophil Infiltration
Interleukin-10
Pneumonia
Cytokines
Streptococcus pneumoniae
Lung
Anti-Inflammatory Agents
Pneumococcal Pneumonia
Bacterial Load
Sinusitis
Otitis Media
Meningitis
Sepsis
Spleen
Inflammation
Mortality
Brain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Citar esto

Peñaloza, H. F., Nieto, P. A., Muñoz-Durango, N., Salazar-Echegarai, F. J., Torres, J., Parga, M. J., ... Bueno, S. M. (2015). Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae. Immunology, 146(1), 100-112. https://doi.org/10.1111/imm.12486
Peñaloza, Hernán F. ; Nieto, Pamela A. ; Muñoz-Durango, Natalia ; Salazar-Echegarai, Francisco J. ; Torres, Javiera ; Parga, María J. ; Alvarez-Lobos, Manuel ; Riedel, Claudia A. ; Kalergis, Alexis M. ; Bueno, Susan M. / Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae. En: Immunology. 2015 ; Vol. 146, N.º 1. pp. 100-112.
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abstract = "Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well as otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation of lungs due to S. pneumoniae infection promotes bacterial dissemination and severe disease. However, the contribution of anti-inflammatory molecules to the pathogenesis of S. pneumoniae remains unknown. To elucidate whether the production of the anti-inflammatory cytokine interleukin-10 (IL-10) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed S. pneumoniae infections in mice lacking IL-10 (IL-10-/- mice). The IL-10-/- mice showed increased mortality, higher expression of pro-inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after S. pneumoniae infection. However, IL-10-/- mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL-10 during S. pneumoniae infection modulates the expression of pro-inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL-10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.",
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Peñaloza, HF, Nieto, PA, Muñoz-Durango, N, Salazar-Echegarai, FJ, Torres, J, Parga, MJ, Alvarez-Lobos, M, Riedel, CA, Kalergis, AM & Bueno, SM 2015, 'Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae', Immunology, vol. 146, n.º 1, pp. 100-112. https://doi.org/10.1111/imm.12486

Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae. / Peñaloza, Hernán F.; Nieto, Pamela A.; Muñoz-Durango, Natalia; Salazar-Echegarai, Francisco J.; Torres, Javiera; Parga, María J.; Alvarez-Lobos, Manuel; Riedel, Claudia A.; Kalergis, Alexis M.; Bueno, Susan M.

En: Immunology, Vol. 146, N.º 1, 01.09.2015, p. 100-112.

Resultado de la investigación: Article

TY - JOUR

T1 - Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae

AU - Peñaloza, Hernán F.

AU - Nieto, Pamela A.

AU - Muñoz-Durango, Natalia

AU - Salazar-Echegarai, Francisco J.

AU - Torres, Javiera

AU - Parga, María J.

AU - Alvarez-Lobos, Manuel

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

AU - Bueno, Susan M.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well as otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation of lungs due to S. pneumoniae infection promotes bacterial dissemination and severe disease. However, the contribution of anti-inflammatory molecules to the pathogenesis of S. pneumoniae remains unknown. To elucidate whether the production of the anti-inflammatory cytokine interleukin-10 (IL-10) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed S. pneumoniae infections in mice lacking IL-10 (IL-10-/- mice). The IL-10-/- mice showed increased mortality, higher expression of pro-inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after S. pneumoniae infection. However, IL-10-/- mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL-10 during S. pneumoniae infection modulates the expression of pro-inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL-10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.

AB - Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well as otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation of lungs due to S. pneumoniae infection promotes bacterial dissemination and severe disease. However, the contribution of anti-inflammatory molecules to the pathogenesis of S. pneumoniae remains unknown. To elucidate whether the production of the anti-inflammatory cytokine interleukin-10 (IL-10) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed S. pneumoniae infections in mice lacking IL-10 (IL-10-/- mice). The IL-10-/- mice showed increased mortality, higher expression of pro-inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after S. pneumoniae infection. However, IL-10-/- mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL-10 during S. pneumoniae infection modulates the expression of pro-inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL-10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.

KW - Bacterial infection

KW - Cytokines

KW - Lung inflammation

KW - Neutrophils

KW - Systemic bacterial infection

UR - http://www.scopus.com/inward/record.url?scp=84938316618&partnerID=8YFLogxK

U2 - 10.1111/imm.12486

DO - 10.1111/imm.12486

M3 - Article

C2 - 26032199

AN - SCOPUS:84938316618

VL - 146

SP - 100

EP - 112

JO - Immunology

JF - Immunology

SN - 0019-2805

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