Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the ZnII/X/(py)2CO (X = Cl-, N3 -, SO4 2-; (py)2CO=di-2-pyridyl ketone) reaction systems

Kenichi Nishioka, Judd C. Rice, Kavitha Sarma, Hediye Erdjument-Bromage, Janis Werner, Yanming Wang, Sergei Chuikov, Pablo Valenzuela, Paul Tempst, Ruth Steward, John T. Lis, C. David Allis, Danny Reinberg

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

49 Citas (Scopus)


A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.

Idioma originalInglés
Páginas (desde-hasta)719-723
Número de páginas5
PublicaciónInorganic Chemistry Communications
EstadoPublicada - sep 2002

Áreas temáticas de ASJC Scopus

  • Química física y teórica
  • Química inorgánica
  • Química de los materiales


Profundice en los temas de investigación de 'Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn<sup>II</sup>/X/(py)<sub>2</sub>CO (X = Cl<sup>-</sup>, N<sub>3</sub> <sup>-</sup>, SO<sub>4</sub> <sup>2-</sup>; (py)<sub>2</sub>CO=di-2-pyridyl ketone) reaction systems'. En conjunto forman una huella única.

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