TY - JOUR
T1 - Insight into nanoparticle cellular uptake and intracellular targeting
AU - Yameen, Basit
AU - Choi, Won Il
AU - Vilos, Cristian
AU - Swami, Archana
AU - Shi, Jinjun
AU - Farokhzad, Omid C.
N1 - Funding Information:
This work was supported by the National Cancer Institute (NCI) (grant U54-CA151884 ), the National Heart, Lung, and Blood Institute (NHLBI) Program of Excellence in Nanotechnology (PEN) (contract # HHSN268201000045C ), the National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01 grant ( EB015419-01 ), the National Research Foundation of Korea ( K1A1A2048701 ), Movember Challenge Award from Prostate Cancer Foundation , and the David Koch–Prostate Cancer Foundation Award in Nanotherapeutics. J.S. thanks the support from NCI R00CA160350 and Prostate Cancer Foundation Young Investigator Award. C.V. acknowledges the support from Center for the Development of Nanoscience and Nanotechnology (Grant FB0807) and the Postdoctoral Program of Becas-Chile/CONICYT.
PY - 2014/9/28
Y1 - 2014/9/28
N2 - Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle-cell interactions for efficient cellular uptake through the plasma membrane and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges. Cellular internalization routes determine the post-internalization fate and intracellular localization of nanoparticles. This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine and presents an account of ligand-targeted nanoparticles for receptor-mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles. Ligand-targeted nanoparticles have been the main impetus behind the progress of nanomedicines towards the clinic. This strategy has already resulted in remarkable progress towards effective oral delivery of nanomedicines that can overcome the intestinal epithelial barrier. A detailed overview of the recent developments in subcellular targeting as a novel platform for next-generation organelle-specific nanomedicines is also provided. Each section of the review includes prospects, potential, and concrete expectations from the field of targeted nanomedicines and strategies to meet those expectations.
AB - Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle-cell interactions for efficient cellular uptake through the plasma membrane and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges. Cellular internalization routes determine the post-internalization fate and intracellular localization of nanoparticles. This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine and presents an account of ligand-targeted nanoparticles for receptor-mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles. Ligand-targeted nanoparticles have been the main impetus behind the progress of nanomedicines towards the clinic. This strategy has already resulted in remarkable progress towards effective oral delivery of nanomedicines that can overcome the intestinal epithelial barrier. A detailed overview of the recent developments in subcellular targeting as a novel platform for next-generation organelle-specific nanomedicines is also provided. Each section of the review includes prospects, potential, and concrete expectations from the field of targeted nanomedicines and strategies to meet those expectations.
KW - Intracellular distribution
KW - Nanomedicine
KW - Nanoparticle cellular uptake
KW - Non-targeted and targeted nanoparticles
KW - Subcellular targeting
UR - http://www.scopus.com/inward/record.url?scp=84906781767&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2014.06.038
DO - 10.1016/j.jconrel.2014.06.038
M3 - Review article
C2 - 24984011
AN - SCOPUS:84906781767
SN - 0168-3659
VL - 190
SP - 485
EP - 499
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -