Influencia del sistema nitridérgico en la respuesta contráctil a fenilefrina de anillos de vasos usados en revascularización coronaria

Juan C. Prieto, Gianni Pinardi, Jaime Zamorano, Ernesto Larraín, Cristián Bermúdez, Rodrigo Castillo, Verónica Cisternas, Hugo F. Miranda

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Background: Endothelial dysfunction is associated to a lower production of nitric oxide and a reduction of endothelium mediated vasodilation. Aim: To study the effects of pharmacological agents that modify nitric oxide synthetase (NOS) activity on tension changes induced by phenylephrine in rings of internal mammary and radial arteries and saphenous vein. Material and methods: Vessel rings of 7 to 10 mm length were obtained from 32 patients subjected to coronary vascular surgery. Fourteen samples of radial artery, 12 samples of internal mammary artery and 15 samples of saphenous vein were obtained. A maximal contraction was induced with KCl and dose response curves for phenylephrine (FE) in the absence or presence of L-arginine and L-arginine methyl ester (L-NAME), were constructed. Results: The tension induced by FE in internal mammary artery and saphenous vein reached a maximum, near 90% of 80 mM KCl-induced contraction, but in the radial artery, it reached a maximum of 63% (p <0.05). In all vessels, the dose response curves were significantly shifted to the right by Larginine and to the left by L-NAME. Conclusions: Pre-incubation of human rings with L-ARG or L-NAME, changed the response to FE induced contraction, which may be related to different degrees of endothelial nitric oxide production or NO sensitivity. The basal NO production in radial artery seems to be larger than the other vessels.

Título traducido de la contribuciónModification of phenylephrine induced contraction of human vessel rings by L-arginine and L-arginine methyl ester
Idioma originalEspañol
Páginas (desde-hasta)1231-1236
Número de páginas6
PublicaciónRevista Medica de Chile
Volumen135
N.º10
EstadoPublicada - oct. 2007

Palabras clave

  • Endothelium, vascular
  • Nitric oxide
  • Phenylephrine

Áreas temáticas de ASJC Scopus

  • Medicina (todo)

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