Infecciones causadas por clostridium difficile: Una visión actualizada

Cristian Hernández-Rocha, Sebastián Naour, Manuel Álvarez-Lobos, Daniel Paredes-Sabja

Resultado de la investigación: Review article

12 Citas (Scopus)

Resumen

Clostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of ~ 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. diffi cile associated infections (CDAI) is ~ 1% of total hospitalized patients. CDAI has a mortality rate of ~1 to 5%, and a relapse rate of ~ 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. diffi cile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.

Idioma originalSpanish
Páginas (desde-hasta)434-445
Número de páginas12
PublicaciónRevista Chilena de Infectologia
Volumen29
N.º4
DOI
EstadoPublished - ago 2012

Huella dactilar

Clostridium difficile
Infection
Spores
Diarrhea
Toxic Megacolon
Pseudomembranous Enterocolitis
Enterotoxins
Virulence Factors
Disease Outbreaks
Epidemiology
Anti-Bacterial Agents
Recurrence
Mortality
Incidence
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Citar esto

Hernández-Rocha, Cristian ; Naour, Sebastián ; Álvarez-Lobos, Manuel ; Paredes-Sabja, Daniel. / Infecciones causadas por clostridium difficile : Una visión actualizada. En: Revista Chilena de Infectologia. 2012 ; Vol. 29, N.º 4. pp. 434-445.
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abstract = "Clostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of ~ 30{\%} of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. diffi cile associated infections (CDAI) is ~ 1{\%} of total hospitalized patients. CDAI has a mortality rate of ~1 to 5{\%}, and a relapse rate of ~ 20{\%}. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. diffi cile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.",
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Infecciones causadas por clostridium difficile : Una visión actualizada. / Hernández-Rocha, Cristian; Naour, Sebastián; Álvarez-Lobos, Manuel; Paredes-Sabja, Daniel.

En: Revista Chilena de Infectologia, Vol. 29, N.º 4, 08.2012, p. 434-445.

Resultado de la investigación: Review article

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