Infecciones causadas por clostridium difficile: Una visión actualizada

Cristian Hernández-Rocha, Sebastián Naour, Manuel Álvarez-Lobos, Daniel Paredes-Sabja

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

12 Citas (Scopus)

Resumen

Clostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of ~ 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. diffi cile associated infections (CDAI) is ~ 1% of total hospitalized patients. CDAI has a mortality rate of ~1 to 5%, and a relapse rate of ~ 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. diffi cile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.

Título traducido de la contribuciónClostridium difficile associated infections: An updated view
Idioma originalEspañol
Páginas (desde-hasta)434-445
Número de páginas12
PublicaciónRevista Chilena de Infectologia
Volumen29
N.º4
DOI
EstadoPublicada - ago 2012

Palabras clave

  • Antibiotic associated colitis
  • C. difficile
  • Cdai
  • Pseudomembranous colitis
  • Spores
  • Toxic megacolon

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas

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