@article{980622c8c9b448fd95450c5baa5e5ab0,
title = "Indomethacin increases severity of Clostridium difficile infection in mouse model",
abstract = "Aim: To evaluate the effect on the nonsteroidal anti-inflammatory drug indomethacin on Clostridium difficile infection (CDI) severity. Materials & methods: Indomethacin was administered in two different mouse models of antibiotic-associated CDI in two different facilities, using a low and high dose of indomethacin. Results: Indomethacin administration caused weight loss, increased the signs of severe infection and worsened histopathological damage, leading to 100% mortality during CDI. Indomethacin-treated, antibiotic-exposed mice infected with C. difficile had enhanced intestinal inflammation with increased expression of KC, IL-1β and IL-22 compared with infected mice unexposed to indomethacin. Conclusion: These results demonstrate a negative impact of nonsteroidal anti-inflammatory drugs on antibiotic-associated CDI in mice and suggest that targeting the synthesis or signaling of prostaglandins might be an approach to ameliorating the severity of CDI.",
keywords = "Prostaglandins",
author = "Juan Mu{\~n}oz-Miralles and Trindade, {Bruno C.} and Pablo Castro-C{\'o}rdova and Bergin, {Ingrid L.} and Kirk, {Leslie A.} and Fernando Gil and Aronoff, {David M.} and Daniel Paredes-Sabja",
note = "Funding Information: This work was supported by Fondo Nacional de Ciencia y Tecnolog{\'i}a de Chile (FONDECYT grant 1151025), from the and by a grant from Fondo de Fomento al Desarrollo Cient{\'i}fico y Tecnol{\'o}gico (FONDEF) ID16|10038 to D Paredes-Sabja and by a doctoral fellowship to P Castro-C{\'o}rdova (CONICYT 21161395). DM Aronoff and his team were funded by the NIH grants TR001723, AI121796 and the Vanderbilt Digestive Diseases Research Center NIH grant DK058404. BC Trindade was funded by a grant from the CAPES (grant number BEX 9179/11-9). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd.",
year = "2018",
month = sep,
day = "1",
doi = "10.2217/fmb-2017-0311",
language = "English",
volume = "13",
pages = "1271--1281",
journal = "Future Microbiology",
issn = "1746-0913",
publisher = "Taylor and Francis Ltd.",
number = "11",
}