Inactivation of Glutamine Synthetase-Coding Gene glnA Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in Salmonella enterica Serovar Typhi

Keyphrases

• Agar Well Diffusion 9%
• Antimicrobial 9%
• Antimicrobial Activity 9%
• Ciprofloxacin 81%
• Coding Genes 100%
• Decreased Expression 9%
• Gene Expression 9%
• Genetic Constructs 9%
• GlnA 100%
• Glutamine Synthetase 100%
• Increased Vulnerability 9%
• Interrupted Gene 9%
• MIC Assay 9%
• MicF 18%
• Nalidixic Acid 9%
• Negative Regulator 9%
• New Antimicrobials 9%
• New Targets 9%
• NtrC 9%
• Null mutant 18%
• OmpF 72%
• Outer Membrane Protein 9%
• Outer Membrane Protein F 100%
• Possible Mechanisms 9%
• Protein Expression 9%
• Quantitative PCR 9%
• Quinolones 100%
• Reduced Susceptibility 18%
• Salmonella Typhi (S. Typhi) 100%
• Site-directed mutagenesis 9%
• Small Interfering RNA (siRNA) 9%
• Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) 9%
• Tetracycline-inducible 9%
• Tn5 Transposase 18%
• Transposon Insertion 9%
• Transposon mutants 9%
• Two-component System 9%

Immunology and Microbiology

• Agar Diffusion 50%
• Antimicrobial Activity 50%
• Infectious Agent 50%
• Minimum Inhibitory Concentration 50%
• Outer Membrane 100%
• Promoter Region 50%
• Real Time Polymerase Chain Reaction 50%
• Salmonella Enterica Serovar Typhi 100%
• Site Directed Mutagenesis 50%
• Transposon 100%