In vivo biocompatibility of the PLGA microparticles in parotid gland

Mario Cantín, Patricio Miranda, Iván Suazo Galdames, Daniela Zavando, Patricia Arenas, Luis Velásquez, Cristian Vilos

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)


Poly(lactic-co-glycolic acid) (PLGA) microparticles are used in various disorders for the controlled or sustained release of drugs, with the management of salivary gland pathologies possible using this technology. There is no record of the response to such microparticles in the glandular parenchyma. The purpose of this study was to assess the morphological changes in the parotid gland when injected with a single dose of PLGA microparticles. We used 12 adult female Sprague Dawley rats (Rattus norvegicus) that were injected into their right parotid gland with sterile vehicle solution (G1, n=4), 0.5 mg PLGA microparticles (G2, n=4), and 0.75 mg PLGA microparticles (G3, n=4); the microparticles were dissolved in a sterile vehicle solution. The intercalar and striated ducts lumen, the thickness of the acini and the histology aspect in terms of the parenchyma organization, cell morphology of acini and duct system, the presence of polymeric residues, and inflammatory response were determined at 14 days post-injection. The administration of the compound in a single dose modified some of the morphometric parameters of parenchyma (intercalar duct lumen and thickness of the glandular acini) but did not induce tissue inflammatory response, despite the visible presence of polymer waste. This suggests that PLGA microparticles are biocompatible with the parotid tissue, making it possible to use intraglandular controlled drug administration.

Idioma originalInglés
Páginas (desde-hasta)2412-2418
Número de páginas7
PublicaciónInternational Journal of Clinical and Experimental Pathology
EstadoPublicada - 2013

Áreas temáticas de ASJC Scopus

  • Patología y medicina forense
  • Histología


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