Imprinting of maternal thyroid hormones in the offspring

María Cecilia Opazo, Henny Haensgen, Karen Bohmwald, Luis F. Venegas, Helene Boudin, Alvaro A. Elorza, Felipe Simon, Carlos Fardella, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Resultado de la investigación: Review article

2 Citas (Scopus)

Resumen

Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation. On the other hand, little is known about the effects of TH deficiency in the offspring immune system, being the prevalent notion that the effects are reversible and only for a while will affect the number of B and T cells. Recent studies have shown that maternal hypothyroidism can altered the function of immune system in the offspring, rendering the female offspring more susceptible to suffer autoimmune-inflammatory diseases, such as experimental autoimmune encephalomyelitis (EAE) and to be more resistant to a bacterial infection. In this article we discuss these recent findings, as well as the possible mechanisms underlying these effects and the potential implications for human health.

Idioma originalEnglish
Páginas (desde-hasta)240-255
Número de páginas16
PublicaciónInternational Reviews of Immunology
Volumen36
N.º4
DOI
EstadoPublished - 4 jul 2017

Huella dactilar

Thyroid Hormones
Mothers
Hypothyroidism
Immune System
Central Nervous System
Pregnancy
Autoimmune Experimental Encephalomyelitis
Bacterial Infections
Intellectual Disability
Autoimmune Diseases
Fetus
B-Lymphocytes
T-Lymphocytes
Imprinting (Psychology)
Health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Citar esto

Opazo, María Cecilia ; Haensgen, Henny ; Bohmwald, Karen ; Venegas, Luis F. ; Boudin, Helene ; Elorza, Alvaro A. ; Simon, Felipe ; Fardella, Carlos ; Bueno, Susan M. ; Kalergis, Alexis M. ; Riedel, Claudia A. / Imprinting of maternal thyroid hormones in the offspring. En: International Reviews of Immunology. 2017 ; Vol. 36, N.º 4. pp. 240-255.
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title = "Imprinting of maternal thyroid hormones in the offspring",
abstract = "Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation. On the other hand, little is known about the effects of TH deficiency in the offspring immune system, being the prevalent notion that the effects are reversible and only for a while will affect the number of B and T cells. Recent studies have shown that maternal hypothyroidism can altered the function of immune system in the offspring, rendering the female offspring more susceptible to suffer autoimmune-inflammatory diseases, such as experimental autoimmune encephalomyelitis (EAE) and to be more resistant to a bacterial infection. In this article we discuss these recent findings, as well as the possible mechanisms underlying these effects and the potential implications for human health.",
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Opazo, MC, Haensgen, H, Bohmwald, K, Venegas, LF, Boudin, H, Elorza, AA, Simon, F, Fardella, C, Bueno, SM, Kalergis, AM & Riedel, CA 2017, 'Imprinting of maternal thyroid hormones in the offspring', International Reviews of Immunology, vol. 36, n.º 4, pp. 240-255. https://doi.org/10.1080/08830185.2016.1277216

Imprinting of maternal thyroid hormones in the offspring. / Opazo, María Cecilia; Haensgen, Henny; Bohmwald, Karen; Venegas, Luis F.; Boudin, Helene; Elorza, Alvaro A.; Simon, Felipe; Fardella, Carlos; Bueno, Susan M.; Kalergis, Alexis M.; Riedel, Claudia A.

En: International Reviews of Immunology, Vol. 36, N.º 4, 04.07.2017, p. 240-255.

Resultado de la investigación: Review article

TY - JOUR

T1 - Imprinting of maternal thyroid hormones in the offspring

AU - Opazo, María Cecilia

AU - Haensgen, Henny

AU - Bohmwald, Karen

AU - Venegas, Luis F.

AU - Boudin, Helene

AU - Elorza, Alvaro A.

AU - Simon, Felipe

AU - Fardella, Carlos

AU - Bueno, Susan M.

AU - Kalergis, Alexis M.

AU - Riedel, Claudia A.

PY - 2017/7/4

Y1 - 2017/7/4

N2 - Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation. On the other hand, little is known about the effects of TH deficiency in the offspring immune system, being the prevalent notion that the effects are reversible and only for a while will affect the number of B and T cells. Recent studies have shown that maternal hypothyroidism can altered the function of immune system in the offspring, rendering the female offspring more susceptible to suffer autoimmune-inflammatory diseases, such as experimental autoimmune encephalomyelitis (EAE) and to be more resistant to a bacterial infection. In this article we discuss these recent findings, as well as the possible mechanisms underlying these effects and the potential implications for human health.

AB - Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation. On the other hand, little is known about the effects of TH deficiency in the offspring immune system, being the prevalent notion that the effects are reversible and only for a while will affect the number of B and T cells. Recent studies have shown that maternal hypothyroidism can altered the function of immune system in the offspring, rendering the female offspring more susceptible to suffer autoimmune-inflammatory diseases, such as experimental autoimmune encephalomyelitis (EAE) and to be more resistant to a bacterial infection. In this article we discuss these recent findings, as well as the possible mechanisms underlying these effects and the potential implications for human health.

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KW - hypothyroxinemia

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