Impairment of aversive memory reconsolidation by localized intracranial electrical stimulation

Jimmy Stehberg, Dino Levy, Abraham Zangen

Resultado de la investigación: Article

18 Citas (Scopus)

Resumen

Reconsolidation of long-term memory is blocked in animal models by macromolecular synthesis inhibitors, resulting in item-specific post-retrieval amnesia. The induction of such amnesia could ameliorate traumatic memories and phobias. However, this pharmacological approach is of limited value in humans because of toxicity. Here we report that reconsolidation of conditioned taste aversion in the rat is impaired by localized intracranial electrical stimulation. Lasting impairment was obtained only when stimulation was applied during memory reactivation and only to the dysgranular insular cortex bilaterally, which subserves the memory, but not to adjacent brain sites. The ability to learn a new association was not affected. The same method blocked new memory consolidation, but produced anterograde amnesia, reminiscent of the known effect of non-localized electroconvulsive therapy. Our results suggest that localized electrical microstimulation, such as produced by deep-brain stimulation or deep transcranial magnetic stimulation, could be used to impair long-term memory if applied during memory reactivation, and could lead to the development of a novel treatment for intractable post-traumatic stress disorder.

Idioma originalEnglish
Páginas (desde-hasta)964-969
Número de páginas6
PublicaciónEuropean Journal of Neuroscience
Volumen29
N.º5
DOI
EstadoPublished - mar 2009

Huella dactilar

Electric Stimulation
Amnesia
Long-Term Memory
Anterograde Amnesia
Electroconvulsive Therapy
Aptitude
Deep Brain Stimulation
Transcranial Magnetic Stimulation
Phobic Disorders
Post-Traumatic Stress Disorders
Cerebral Cortex
Animal Models
Pharmacology
Brain
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Citar esto

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Impairment of aversive memory reconsolidation by localized intracranial electrical stimulation. / Stehberg, Jimmy; Levy, Dino; Zangen, Abraham.

En: European Journal of Neuroscience, Vol. 29, N.º 5, 03.2009, p. 964-969.

Resultado de la investigación: Article

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