Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia

Sven Niklander, Flavio Fuentes, Daniela Sanchez, Verónica Araya, Giuliana Chiappini, René Martinez, Maureen Marshall

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Dry mouth sensation, also known as xerostomia, is a common clinical problem with an increasing prevalence. Although recent studies have reported promissory results of malic acid, none have evaluated the impact of malic acid on the oral health-related quality of life (OHRQoL) of patients with xerostomia. Thus, this study aimed to evaluate the impact of 1% malic acid, combined with fluoride and xylitol, on the OHRQoL of patients with xerostomia. We enrolled 70 patients and randomly allocated them into two groups: the intervention group (applied topical sialogogue with 1% malic acid) and the control group (applied a placebo). We assessed the OHRQoL and severity of xerostomia before and after treatment with the Spanish version of the Oral Health Impact Profile-14 questionnaire (OHIP-14sp) and a visual analogue scale (VAS), respectively. In addition, stimulated and non-stimulated salivary flow rates before and after treatments were also measured. In total, 60 patients completed the study. According to the VAS, both sprays significantly improved dry mouth sensation (P < 0.001). However, OHIP-14sp total scores decreased significantly in the intervention group from 20.8 ± 10.4 to 16.5 ± 9.5 (P < 0.001), indicating an improvement in the OHRQoL. No significant differ- ences were observed in the control group (P > 0.05). Furthermore, non-stimulated salivary flow rates significantly increased in the intervention group from 0.25 ± 0.22 to 0.33 ± 0.33 mL/min (P < 0.001). Overall, this study demonstrated that malic acid improves the OHRQoL and dry mouth sensation in patients with xerostomia.

Idioma originalEnglish
Páginas (desde-hasta)278-284
Número de páginas7
PublicaciónJournal of oral science
Volumen60
N.º2
DOI
EstadoPublished - 1 jun 2018

Huella dactilar

Xerostomia
Oral Health
Quality of Life
Mouth
Visual Analog Scale
Xylitol
Fluorides
Placebos
malic acid
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Dentistry(all)

Citar esto

Niklander, Sven ; Fuentes, Flavio ; Sanchez, Daniela ; Araya, Verónica ; Chiappini, Giuliana ; Martinez, René ; Marshall, Maureen. / Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia. En: Journal of oral science. 2018 ; Vol. 60, N.º 2. pp. 278-284.
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abstract = "Dry mouth sensation, also known as xerostomia, is a common clinical problem with an increasing prevalence. Although recent studies have reported promissory results of malic acid, none have evaluated the impact of malic acid on the oral health-related quality of life (OHRQoL) of patients with xerostomia. Thus, this study aimed to evaluate the impact of 1{\%} malic acid, combined with fluoride and xylitol, on the OHRQoL of patients with xerostomia. We enrolled 70 patients and randomly allocated them into two groups: the intervention group (applied topical sialogogue with 1{\%} malic acid) and the control group (applied a placebo). We assessed the OHRQoL and severity of xerostomia before and after treatment with the Spanish version of the Oral Health Impact Profile-14 questionnaire (OHIP-14sp) and a visual analogue scale (VAS), respectively. In addition, stimulated and non-stimulated salivary flow rates before and after treatments were also measured. In total, 60 patients completed the study. According to the VAS, both sprays significantly improved dry mouth sensation (P < 0.001). However, OHIP-14sp total scores decreased significantly in the intervention group from 20.8 ± 10.4 to 16.5 ± 9.5 (P < 0.001), indicating an improvement in the OHRQoL. No significant differ- ences were observed in the control group (P > 0.05). Furthermore, non-stimulated salivary flow rates significantly increased in the intervention group from 0.25 ± 0.22 to 0.33 ± 0.33 mL/min (P < 0.001). Overall, this study demonstrated that malic acid improves the OHRQoL and dry mouth sensation in patients with xerostomia.",
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Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia. / Niklander, Sven; Fuentes, Flavio; Sanchez, Daniela; Araya, Verónica; Chiappini, Giuliana; Martinez, René; Marshall, Maureen.

En: Journal of oral science, Vol. 60, N.º 2, 01.06.2018, p. 278-284.

Resultado de la investigación: Article

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AU - Niklander, Sven

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AU - Sanchez, Daniela

AU - Araya, Verónica

AU - Chiappini, Giuliana

AU - Martinez, René

AU - Marshall, Maureen

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