Immune responses to infectious laryngotracheitis virus

Mauricio J.C. Coppo, Carol A. Hartley, Joanne M. Devlin

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

49 Citas (Scopus)

Resumen

Infectious laryngotracheitis (ILT) is an upper respiratory tract disease in chickens caused by infectious laryngotracheitis virus (ILTV), an alphaherpesvirus. Despite the extensive use of attenuated, and more recently recombinant, vaccines for the control of this disease, ILT continues to affect the intensive poultry industries worldwide. Innate and cell-mediated, rather than humoral immune responses, have been identified as responsible for protection against disease. This review examines the current understandings in innate and adaptive immune responses towards ILTV, as well as the role of ILTV glycoprotein G in modulating the host immune response towards infection. Protective immunity induced by ILT vaccines is also examined. The increasing availability of tools and reagents for the characterisation of avian innate and cell-mediated immune responses are expected to further our understanding of immunity against ILTV and drive the development of new generation vaccines towards enhanced control of this disease.

Idioma originalInglés
Páginas (desde-hasta)454-462
Número de páginas9
PublicaciónDevelopmental and Comparative Immunology
Volumen41
N.º3
DOI
EstadoPublicada - nov. 2013
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Inmunología
  • Biología del desarrollo

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