Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation

J. Jain, J. Moreno, R. Andaur, R. Armisen, D. Morales, K. Marcelain, G. Avaria, B. Bora, S. Davis, C. Pavez, L. Soto

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.

Idioma originalEnglish
Número de artículo085121
PublicaciónAIP Advances
Volumen7
N.º8
DOI
EstadoPublished - 1 ago 2017

Huella dactilar

plasma focus
cancer
irradiation
pulsed radiation
neutrons
death
dosage
neutron irradiation
thermoluminescence
pulses
cultured cells
dosimeters
fluence
x rays
deoxyribonucleic acid
damage
energy
detectors
estimates

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Citar esto

Jain, J., Moreno, J., Andaur, R., Armisen, R., Morales, D., Marcelain, K., ... Soto, L. (2017). Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation. AIP Advances, 7(8), [085121]. https://doi.org/10.1063/1.4994655
Jain, J. ; Moreno, J. ; Andaur, R. ; Armisen, R. ; Morales, D. ; Marcelain, K. ; Avaria, G. ; Bora, B. ; Davis, S. ; Pavez, C. ; Soto, L. / Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation. En: AIP Advances. 2017 ; Vol. 7, N.º 8.
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Jain, J, Moreno, J, Andaur, R, Armisen, R, Morales, D, Marcelain, K, Avaria, G, Bora, B, Davis, S, Pavez, C & Soto, L 2017, 'Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation', AIP Advances, vol. 7, n.º 8, 085121. https://doi.org/10.1063/1.4994655

Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation. / Jain, J.; Moreno, J.; Andaur, R.; Armisen, R.; Morales, D.; Marcelain, K.; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Soto, L.

En: AIP Advances, Vol. 7, N.º 8, 085121, 01.08.2017.

Resultado de la investigación: Article

TY - JOUR

T1 - Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation

AU - Jain, J.

AU - Moreno, J.

AU - Andaur, R.

AU - Armisen, R.

AU - Morales, D.

AU - Marcelain, K.

AU - Avaria, G.

AU - Bora, B.

AU - Davis, S.

AU - Pavez, C.

AU - Soto, L.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.

AB - Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely "PF-400J", was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.

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Jain J, Moreno J, Andaur R, Armisen R, Morales D, Marcelain K y otros. Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation. AIP Advances. 2017 ago 1;7(8). 085121. https://doi.org/10.1063/1.4994655