Human milk oligosaccharides and health promotion through the gut microbiome

Pamela Thomson, Daniel Garrido

Resultado de la investigación: Contribución a los tipos de informe/libroCapítulorevisión exhaustiva

1 Cita (Scopus)

Resumen

Breast milk is the gold standard in infant nutrition. In addition to promoting proper growth, it contains multiple bioactive molecules that help in infant protection and development. Human milk oligosaccharides (HMO) are complex carbohydrates abundant in breast milk, which are not used as energy by the infant. In turn, these oligosaccharides guide and support the assembly of a healthy gut microbiome, stimulating the growth of beneficial microbes such as Bifidobacterium. The structures of these complex glycans are being unraveled, as well as the molecular mechanisms of infant gut-associated Bifidobacterium to utilize these substrates and predominate in the microbiome. Moreover, the role of other glycans in milk proteins and glycolipids in this promotion is being supported. Finally, novel approaches to replicate the structures and roles of milk oligosaccharides in infant health are being actively sought. This chapter presents recent advances related to the role of HMO in promoting health through modulation of the infant gut microbiome, emphasizing the molecular basis of the enrichment in beneficial microbes such as Bifidobacterium.

Idioma originalInglés
Título de la publicación alojadaDairy in Human Health and Disease across the Lifespan
EditorialElsevier Inc.
Páginas73-86
Número de páginas14
ISBN (versión digital)9780128098691
ISBN (versión impresa)9780128098684
DOI
EstadoPublicada - 1 ene 2017
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Ingeniería (todo)
  • Agricultura y biología (todo)

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