Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu

Nibaldo C. Inestrosa, Ariel E. Reyes, Marcelo A. Chacón, Waldo Cerpa, Aldo Villalón, Juan Montiel, Genevieve Merabachvili, Rebeca Aldunate, Francisco Bozinovic, Francisco Aboitiz

Resultado de la investigación: Article

70 Citas (Scopus)

Resumen

It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

Idioma originalEnglish
Páginas (desde-hasta)1023-1028
Número de páginas6
PublicaciónNeurobiology of Aging
Volumen26
N.º7
DOI
EstadoPublished - 1 ene 2005

Huella dactilar

Octodon
Amyloid
Rodentia
Pathology
Alzheimer Disease
Peptides
tau Proteins
Amyloid beta-Protein Precursor
Pyramidal Cells
Amyloid Plaques
Acetylcholinesterase
Ubiquitin
Amino Acids
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Citar esto

Inestrosa, Nibaldo C. ; Reyes, Ariel E. ; Chacón, Marcelo A. ; Cerpa, Waldo ; Villalón, Aldo ; Montiel, Juan ; Merabachvili, Genevieve ; Aldunate, Rebeca ; Bozinovic, Francisco ; Aboitiz, Francisco. / Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu. En: Neurobiology of Aging. 2005 ; Vol. 26, N.º 7. pp. 1023-1028.
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title = "Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu",
abstract = "It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5{\%}) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.",
keywords = "Alzheimer model, Alzheimer's disease, Amyloid-β-peptide, APP, Neuropathology, Octodon degu",
author = "Inestrosa, {Nibaldo C.} and Reyes, {Ariel E.} and Chac{\'o}n, {Marcelo A.} and Waldo Cerpa and Aldo Villal{\'o}n and Juan Montiel and Genevieve Merabachvili and Rebeca Aldunate and Francisco Bozinovic and Francisco Aboitiz",
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Inestrosa, NC, Reyes, AE, Chacón, MA, Cerpa, W, Villalón, A, Montiel, J, Merabachvili, G, Aldunate, R, Bozinovic, F & Aboitiz, F 2005, 'Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu', Neurobiology of Aging, vol. 26, n.º 7, pp. 1023-1028. https://doi.org/10.1016/j.neurobiolaging.2004.09.016

Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu. / Inestrosa, Nibaldo C.; Reyes, Ariel E.; Chacón, Marcelo A.; Cerpa, Waldo; Villalón, Aldo; Montiel, Juan; Merabachvili, Genevieve; Aldunate, Rebeca; Bozinovic, Francisco; Aboitiz, Francisco.

En: Neurobiology of Aging, Vol. 26, N.º 7, 01.01.2005, p. 1023-1028.

Resultado de la investigación: Article

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AU - Inestrosa, Nibaldo C.

AU - Reyes, Ariel E.

AU - Chacón, Marcelo A.

AU - Cerpa, Waldo

AU - Villalón, Aldo

AU - Montiel, Juan

AU - Merabachvili, Genevieve

AU - Aldunate, Rebeca

AU - Bozinovic, Francisco

AU - Aboitiz, Francisco

PY - 2005/1/1

Y1 - 2005/1/1

N2 - It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

AB - It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

KW - Alzheimer model

KW - Alzheimer's disease

KW - Amyloid-β-peptide

KW - APP

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