Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu

Nibaldo C. Inestrosa, Ariel E. Reyes, Marcelo A. Chacón, Waldo Cerpa, Aldo Villalón, Juan Montiel, Genevieve Merabachvili, Rebeca Aldunate, Francisco Bozinovic, Francisco Aboitiz

Resultado de la investigación: Contribución a una revistaArtículo

73 Citas (Scopus)

Resumen

It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

Idioma originalInglés
Páginas (desde-hasta)1023-1028
Número de páginas6
PublicaciónNeurobiology of Aging
Volumen26
N.º7
DOI
EstadoPublicada - 1 ene 2005

Áreas temáticas de ASJC Scopus

  • Neurociencia (todo)
  • Estudio del envejecimiento
  • Neurología clínica
  • Biología del desarrollo
  • Geriatría y gerontología

Huella Profundice en los temas de investigación de 'Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu'. En conjunto forman una huella única.

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    Inestrosa, N. C., Reyes, A. E., Chacón, M. A., Cerpa, W., Villalón, A., Montiel, J., Merabachvili, G., Aldunate, R., Bozinovic, F., & Aboitiz, F. (2005). Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu. Neurobiology of Aging, 26(7), 1023-1028. https://doi.org/10.1016/j.neurobiolaging.2004.09.016