Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu

Nibaldo C. Inestrosa, Ariel E. Reyes, Marcelo A. Chacón, Waldo Cerpa, Aldo Villalón, Juan Montiel, Genevieve Merabachvili, Rebeca Aldunate, Francisco Bozinovic, Francisco Aboitiz

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

80 Citas (Scopus)

Resumen

It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal β-amyloid precursor protein (β-APP695) displaying both intracellular and extracellular deposits of amyloid-β-peptide (Aβ), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAβ and humanAβ sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

Idioma originalInglés
Páginas (desde-hasta)1023-1028
Número de páginas6
PublicaciónNeurobiology of Aging
Volumen26
N.º7
DOI
EstadoPublicada - 1 ene 2005

Áreas temáticas de ASJC Scopus

  • Neurociencia (todo)
  • Estudio del envejecimiento
  • Neurología clínica
  • Biología del desarrollo
  • Geriatría y gerontología

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