Host immunity during RSV pathogenesis

Susan M. Bueno, Pablo A. González, Rodrigo Pacheco, Eduardo D. Leiva, Kelly M. Cautivo, Hugo E. Tobar, Jorge E. Mora, Carolina E. Prado, Juan P. Zúñiga, Jorge Jiménez, Claudia A. Riedel, Alexis M. Kalergis

Resultado de la investigación: Article

61 Citas (Scopus)

Resumen

Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during virus clearance. This exacerbated and inefficient immune-inflammatory response triggered by RSV, has often been attributed to the induction of a Th2-biased immunity specific for some of the RSV antigens. These features of RSV infection suggest that the virus might possess molecular mechanisms to enhance allergic-type immunity in the host in order to prevent clearance by cytotoxic T cells and ensure survival and dissemination to other hosts. In this review, we discuss recent findings that contribute to explain the components of the innate and adaptive immune response that are involved in RSV-mediated disease exacerbation. Further, the virulence mechanisms used by RSV to avoid activation of protective immune responses are described.

Idioma originalEnglish
Páginas (desde-hasta)1320-1329
Número de páginas10
PublicaciónInternational Immunopharmacology
Volumen8
N.º10
DOI
EstadoPublished - 1 oct 2008

Huella dactilar

Respiratory Syncytial Viruses
Respiratory Syncytial Virus Infections
Immunity
Immunologic Memory
Viruses
Adaptive Immunity
Virus Diseases
Innate Immunity
Respiratory System
Virulence
Disease Progression
Cell Survival
Hospitalization
Economics
T-Lymphocytes
Antigens
Health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Citar esto

Bueno, S. M., González, P. A., Pacheco, R., Leiva, E. D., Cautivo, K. M., Tobar, H. E., ... Kalergis, A. M. (2008). Host immunity during RSV pathogenesis. International Immunopharmacology, 8(10), 1320-1329. https://doi.org/10.1016/j.intimp.2008.03.012
Bueno, Susan M. ; González, Pablo A. ; Pacheco, Rodrigo ; Leiva, Eduardo D. ; Cautivo, Kelly M. ; Tobar, Hugo E. ; Mora, Jorge E. ; Prado, Carolina E. ; Zúñiga, Juan P. ; Jiménez, Jorge ; Riedel, Claudia A. ; Kalergis, Alexis M. / Host immunity during RSV pathogenesis. En: International Immunopharmacology. 2008 ; Vol. 8, N.º 10. pp. 1320-1329.
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abstract = "Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during virus clearance. This exacerbated and inefficient immune-inflammatory response triggered by RSV, has often been attributed to the induction of a Th2-biased immunity specific for some of the RSV antigens. These features of RSV infection suggest that the virus might possess molecular mechanisms to enhance allergic-type immunity in the host in order to prevent clearance by cytotoxic T cells and ensure survival and dissemination to other hosts. In this review, we discuss recent findings that contribute to explain the components of the innate and adaptive immune response that are involved in RSV-mediated disease exacerbation. Further, the virulence mechanisms used by RSV to avoid activation of protective immune responses are described.",
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Bueno, SM, González, PA, Pacheco, R, Leiva, ED, Cautivo, KM, Tobar, HE, Mora, JE, Prado, CE, Zúñiga, JP, Jiménez, J, Riedel, CA & Kalergis, AM 2008, 'Host immunity during RSV pathogenesis', International Immunopharmacology, vol. 8, n.º 10, pp. 1320-1329. https://doi.org/10.1016/j.intimp.2008.03.012

Host immunity during RSV pathogenesis. / Bueno, Susan M.; González, Pablo A.; Pacheco, Rodrigo; Leiva, Eduardo D.; Cautivo, Kelly M.; Tobar, Hugo E.; Mora, Jorge E.; Prado, Carolina E.; Zúñiga, Juan P.; Jiménez, Jorge; Riedel, Claudia A.; Kalergis, Alexis M.

En: International Immunopharmacology, Vol. 8, N.º 10, 01.10.2008, p. 1320-1329.

Resultado de la investigación: Article

TY - JOUR

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AU - Bueno, Susan M.

AU - González, Pablo A.

AU - Pacheco, Rodrigo

AU - Leiva, Eduardo D.

AU - Cautivo, Kelly M.

AU - Tobar, Hugo E.

AU - Mora, Jorge E.

AU - Prado, Carolina E.

AU - Zúñiga, Juan P.

AU - Jiménez, Jorge

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

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N2 - Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during virus clearance. This exacerbated and inefficient immune-inflammatory response triggered by RSV, has often been attributed to the induction of a Th2-biased immunity specific for some of the RSV antigens. These features of RSV infection suggest that the virus might possess molecular mechanisms to enhance allergic-type immunity in the host in order to prevent clearance by cytotoxic T cells and ensure survival and dissemination to other hosts. In this review, we discuss recent findings that contribute to explain the components of the innate and adaptive immune response that are involved in RSV-mediated disease exacerbation. Further, the virulence mechanisms used by RSV to avoid activation of protective immune responses are described.

AB - Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during virus clearance. This exacerbated and inefficient immune-inflammatory response triggered by RSV, has often been attributed to the induction of a Th2-biased immunity specific for some of the RSV antigens. These features of RSV infection suggest that the virus might possess molecular mechanisms to enhance allergic-type immunity in the host in order to prevent clearance by cytotoxic T cells and ensure survival and dissemination to other hosts. In this review, we discuss recent findings that contribute to explain the components of the innate and adaptive immune response that are involved in RSV-mediated disease exacerbation. Further, the virulence mechanisms used by RSV to avoid activation of protective immune responses are described.

KW - Dendritic cells

KW - Immune response

KW - Immunopathology

KW - Respiratory syncytial virus

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Bueno SM, González PA, Pacheco R, Leiva ED, Cautivo KM, Tobar HE y otros. Host immunity during RSV pathogenesis. International Immunopharmacology. 2008 oct 1;8(10):1320-1329. https://doi.org/10.1016/j.intimp.2008.03.012