Histone chaperones, a supporting role in the limelight

Alejandra Loyola, Genevieve Almouzni

Resultado de la investigación: Contribución a una revistaArtículo de revisión

264 Citas (Scopus)

Resumen

In eukaryotic cells, highly basic histone proteins are associated with the DNA to form the nucleosome, the fundamental unit of chromatin. Histones are closely escorted by histone chaperones from their point of synthesis up to their delivery site. We will present an overview of the histone chaperones identified to date with their various roles, in an attempt to highlight their importance in cellular metabolism. Nucleoplasmin will illustrate a role in histone storage and Nap-1, a histone translocator. CAF-1 and Hira will provide examples of distinct histone deposition factors coupled to and uncoupled from DNA synthesis, respectively, while Asf1 could act as a histone donor. We then will illustrate with two examples how histone chaperones can be associated with chromatin remodeling activities. Finally, we will discuss how the RbAp46/48 proteins, as escort factors, are part of multiple complexes with various functions. Based on these examples, we will propose a scheme in which the diverse roles of histone chaperones are integrated within an assembly line for chromatin formation and regulation. Finally, we discuss how these chaperones may have more than a supporting role in a histone metabolic pathway.

Idioma originalInglés
Páginas (desde-hasta)3-11
Número de páginas9
PublicaciónBiochimica et Biophysica Acta - Gene Structure and Expression
Volumen1677
N.º1-3
DOI
EstadoPublicada - 15 mar 2004

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biofísica
  • Genética
  • Biología estructural

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