High and low activity rats: Elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats

Claudio E. Perez-Leighton, Kelsey Boland, Charles J. Billington, Catherine M. Kotz

Resultado de la investigación: Article

22 Citas (Scopus)

Resumen

Objective: Humans and rodents show large variability in their individual sensitivity to diet-induced obesity (DIO), which has been associated with differences in intrinsic spontaneous physical activity (SPA). Evidence from genetic and out-bred rat obesity models shows that higher activity of the orexin peptides results in higher intrinsic SPA and protection against DIO. Based on this, we hypothesized that naturally occurring variation in SPA and orexin signaling is sufficient to drive differences in sensitivity to DIO. Design and Methods: Orexin expression, behavioral responses to orexin-A, basal energy expenditure and sensitivity to DIO were measured in in non-manipulated male Sprague-Dawley rats selected for high and low intrinsic SPA. Results: Male Sprague-Dawley rats were classified as high-activity or low-activity based on differences in intrinsic SPA. High-activity rats showed higher expression of prepro-orexin mRNA, higher sensitivity to behavioral effects of orexin injection, higher basal energy expenditure and were more resistant to obesity caused by high-fat diet consumption than low-activity rats. Conclusion: Our results define a new model of differential DIO sensitivity, the high-activity and lowactivity rats, and suggest that naturally occurring variations in intrinsic SPA cause differences in energy expenditure that are mediated by orexin signaling and alter DIO sensitivity.

Idioma originalEnglish
Páginas (desde-hasta)353-360
Número de páginas8
PublicaciónObesity
Volumen21
N.º2
DOI
EstadoPublished - feb 2013

Huella dactilar

Obesity
Diet
Energy Metabolism
Sprague Dawley Rats
High Fat Diet
Rodentia
Messenger RNA
Peptides
Injections

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Citar esto

Perez-Leighton, Claudio E. ; Boland, Kelsey ; Billington, Charles J. ; Kotz, Catherine M. / High and low activity rats : Elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats. En: Obesity. 2013 ; Vol. 21, N.º 2. pp. 353-360.
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High and low activity rats : Elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats. / Perez-Leighton, Claudio E.; Boland, Kelsey; Billington, Charles J.; Kotz, Catherine M.

En: Obesity, Vol. 21, N.º 2, 02.2013, p. 353-360.

Resultado de la investigación: Article

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