Herpes simplex virus type 1 infection of the central nervous system: Insights into proposed interrelationships with neurodegenerative disorders

Luisa F. Duarte, Mónica A. Farías, Diana M. Álvarez, Susan M. Bueno, Claudia A. Riedel, Pablo A. González

Resultado de la investigación: Review article

3 Citas (Scopus)

Resumen

Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.

Idioma originalEnglish
Número de artículo46
Páginas (desde-hasta)1-23
Número de páginas23
PublicaciónFrontiers in Cellular Neuroscience
Volumen13
DOI
EstadoPublished - 29 ene 2019

Huella dactilar

Human Herpesvirus 1
Virus Diseases
Neurodegenerative Diseases
Central Nervous System
Encephalitis
Acute Hemorrhagic Leukoencephalitis
Brain
Viruses
Autophagy
Virus Replication
Cognition
Antiviral Agents
Apoptosis
Neurons
Infection
Proteins

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Citar esto

Duarte, Luisa F. ; Farías, Mónica A. ; Álvarez, Diana M. ; Bueno, Susan M. ; Riedel, Claudia A. ; González, Pablo A. / Herpes simplex virus type 1 infection of the central nervous system : Insights into proposed interrelationships with neurodegenerative disorders. En: Frontiers in Cellular Neuroscience. 2019 ; Vol. 13. pp. 1-23.
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abstract = "Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.",
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Herpes simplex virus type 1 infection of the central nervous system : Insights into proposed interrelationships with neurodegenerative disorders. / Duarte, Luisa F.; Farías, Mónica A.; Álvarez, Diana M.; Bueno, Susan M.; Riedel, Claudia A.; González, Pablo A.

En: Frontiers in Cellular Neuroscience, Vol. 13, 46, 29.01.2019, p. 1-23.

Resultado de la investigación: Review article

TY - JOUR

T1 - Herpes simplex virus type 1 infection of the central nervous system

T2 - Insights into proposed interrelationships with neurodegenerative disorders

AU - Duarte, Luisa F.

AU - Farías, Mónica A.

AU - Álvarez, Diana M.

AU - Bueno, Susan M.

AU - Riedel, Claudia A.

AU - González, Pablo A.

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.

AB - Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.

KW - Apoptosis

KW - Autophagy

KW - Herpes simplex virus

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