Hemichannels: New roles in astroglial function

Juan A. Orellana, Jimmy Stehberg

Resultado de la investigación: Review article

48 Citas (Scopus)

Resumen

The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of "gliotransmitters."Astrocytes express receptors for most neurotransmitters and respond to them through Ca2+ intracellular oscillations and propagation of intercellular Ca2+ waves. While such waves are able to propagate among neighboring astrocytes through gap junctions, thereby activating several astrocytes simultaneously, they can also trigger the release of gliotransmitters, including glutamate, d-serine, glycine, ATP, adenosine, or GABA. There are several mechanisms by which gliotransmitter release occurs, including functional hemichannels. These gliotransmitters can activate neighboring astrocytes and participate in the propagation of intercellular Ca2+ waves, or activate pre- and post-synaptic receptors, including NMDA, AMPA, and purinergic receptors. In consequence, hemichannels could play a pivotal role in astrocyte-to-astrocyte communication and astrocyte-to-neuron cross-talk. Recent evidence suggests that astroglial hemichannels are involved in higher brain functions including memory and glucose sensing. The present review will focus on the role of hemichannels in astrocyte-to-astrocyte and astrocyte-to neuron communication and in brain physiology.

Idioma originalEnglish
Número de artículoArticle 193
PublicaciónFrontiers in Physiology
Volumen5 JUN
DOI
EstadoPublished - 2014

Huella dactilar

Astrocytes
Neurotransmitter Receptor
Brain
Communication
Neurons
Purinergic Receptors
AMPA Receptors
Gap Junctions
N-Methyl-D-Aspartate Receptors
Adenosine
Synapses
Glycine
gamma-Aminobutyric Acid
Serine
Glutamic Acid
Adenosine Triphosphate
Glucose

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Citar esto

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Hemichannels : New roles in astroglial function. / Orellana, Juan A.; Stehberg, Jimmy.

En: Frontiers in Physiology, Vol. 5 JUN, Article 193, 2014.

Resultado de la investigación: Review article

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AU - Stehberg, Jimmy

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