Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

Beatriz Escobar, Iván Montenegro, Joan Villena, Enrique Werner, Patricio Godoy, Yusser Olguín, Alejandro Madrid

Resultado de la investigación: Article

2 Citas (Scopus)

Resumen

An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.

Idioma originalEnglish
Número de artículo968
PublicaciónMolecules
Volumen22
N.º6
DOI
EstadoPublished - 1 jun 2017

Huella dactilar

Oomycetes
Saprolegnia
Thermodynamic properties
analogs
synthesis
Nuclear magnetic resonance
nuclear magnetic resonance
spores
Mycelium
Assays
Microbial Sensitivity Tests
Spores
Derivatives
isocordoin

ASJC Scopus subject areas

  • Medicine(all)
  • Organic Chemistry

Citar esto

Escobar, B., Montenegro, I., Villena, J., Werner, E., Godoy, P., Olguín, Y., & Madrid, A. (2017). Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules, 22(6), [968]. https://doi.org/10.3390/molecules22060968
Escobar, Beatriz ; Montenegro, Iván ; Villena, Joan ; Werner, Enrique ; Godoy, Patricio ; Olguín, Yusser ; Madrid, Alejandro. / Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. En: Molecules. 2017 ; Vol. 22, N.º 6.
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abstract = "An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.",
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Escobar, B, Montenegro, I, Villena, J, Werner, E, Godoy, P, Olguín, Y & Madrid, A 2017, 'Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin', Molecules, vol. 22, n.º 6, 968. https://doi.org/10.3390/molecules22060968

Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. / Escobar, Beatriz; Montenegro, Iván; Villena, Joan; Werner, Enrique; Godoy, Patricio; Olguín, Yusser; Madrid, Alejandro.

En: Molecules, Vol. 22, N.º 6, 968, 01.06.2017.

Resultado de la investigación: Article

TY - JOUR

T1 - Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

AU - Escobar, Beatriz

AU - Montenegro, Iván

AU - Villena, Joan

AU - Werner, Enrique

AU - Godoy, Patricio

AU - Olguín, Yusser

AU - Madrid, Alejandro

PY - 2017/6/1

Y1 - 2017/6/1

N2 - An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.

AB - An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.

KW - Anti-oomycete activity

KW - Isocordoin

KW - Oxyalkyl derivates

KW - Saprolegnia sp.

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Escobar B, Montenegro I, Villena J, Werner E, Godoy P, Olguín Y y otros. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules. 2017 jun 1;22(6). 968. https://doi.org/10.3390/molecules22060968