Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

Valentina P. Sebastián, Geraldyne A. Salazar, Irenice Coronado-Arrázola, Bárbara M. Schultz, Omar P. Vallejos, Loni Berkowitz, Manuel M. Álvarez-Lobos, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno

Resultado de la investigación: Review article

5 Citas (Scopus)

Resumen

Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease.

Idioma originalEnglish
Número de artículo1956
PublicaciónFrontiers in Immunology
Volumen9
N.ºSEP
DOI
EstadoPublished - 12 sep 2018

Huella dactilar

Heme Oxygenase-1
Inflammation
Carbon Monoxide
Microbiota
Biliverdine
Myoglobin
Infection
Heme
Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
Cytochrome P-450 Enzyme System
Hemoglobins
Pharmacology
Enzymes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Citar esto

Sebastián, V. P., Salazar, G. A., Coronado-Arrázola, I., Schultz, B. M., Vallejos, O. P., Berkowitz, L., ... Bueno, S. M. (2018). Heme oxygenase-1 as a modulator of intestinal inflammation development and progression. Frontiers in Immunology, 9(SEP), [1956]. https://doi.org/10.3389/fimmu.2018.01956
Sebastián, Valentina P. ; Salazar, Geraldyne A. ; Coronado-Arrázola, Irenice ; Schultz, Bárbara M. ; Vallejos, Omar P. ; Berkowitz, Loni ; Álvarez-Lobos, Manuel M. ; Riedel, Claudia A. ; Kalergis, Alexis M. ; Bueno, Susan M. / Heme oxygenase-1 as a modulator of intestinal inflammation development and progression. En: Frontiers in Immunology. 2018 ; Vol. 9, N.º SEP.
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abstract = "Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease.",
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Sebastián, VP, Salazar, GA, Coronado-Arrázola, I, Schultz, BM, Vallejos, OP, Berkowitz, L, Álvarez-Lobos, MM, Riedel, CA, Kalergis, AM & Bueno, SM 2018, 'Heme oxygenase-1 as a modulator of intestinal inflammation development and progression', Frontiers in Immunology, vol. 9, n.º SEP, 1956. https://doi.org/10.3389/fimmu.2018.01956

Heme oxygenase-1 as a modulator of intestinal inflammation development and progression. / Sebastián, Valentina P.; Salazar, Geraldyne A.; Coronado-Arrázola, Irenice; Schultz, Bárbara M.; Vallejos, Omar P.; Berkowitz, Loni; Álvarez-Lobos, Manuel M.; Riedel, Claudia A.; Kalergis, Alexis M.; Bueno, Susan M.

En: Frontiers in Immunology, Vol. 9, N.º SEP, 1956, 12.09.2018.

Resultado de la investigación: Review article

TY - JOUR

T1 - Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

AU - Sebastián, Valentina P.

AU - Salazar, Geraldyne A.

AU - Coronado-Arrázola, Irenice

AU - Schultz, Bárbara M.

AU - Vallejos, Omar P.

AU - Berkowitz, Loni

AU - Álvarez-Lobos, Manuel M.

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

AU - Bueno, Susan M.

PY - 2018/9/12

Y1 - 2018/9/12

N2 - Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease.

AB - Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease.

KW - Carbon monoxide

KW - Colorectal cancer

KW - Heme oxygenase-1

KW - Infection

KW - Inflammation

KW - Inflammatory bowel disease

KW - Microbiota

KW - Nuclear factor erythroid 2-related factor 2

UR - http://www.scopus.com/inward/record.url?scp=85053159931&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.01956

DO - 10.3389/fimmu.2018.01956

M3 - Review article

AN - SCOPUS:85053159931

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - SEP

M1 - 1956

ER -

Sebastián VP, Salazar GA, Coronado-Arrázola I, Schultz BM, Vallejos OP, Berkowitz L y otros. Heme oxygenase-1 as a modulator of intestinal inflammation development and progression. Frontiers in Immunology. 2018 sep 12;9(SEP). 1956. https://doi.org/10.3389/fimmu.2018.01956