TY - JOUR
T1 - Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases
AU - Mendoza-León, María José
AU - Mangalam, Ashutosh K.
AU - Regaldiz, Alejandro
AU - González-Madrid, Enrique
AU - Rangel-Ramírez, Ma Andreina
AU - Álvarez-Mardonez, Oscar
AU - Vallejos, Omar P.
AU - Méndez, Constanza
AU - Bueno, Susan M.
AU - Melo-González, Felipe
AU - Duarte, Yorley
AU - Opazo, Ma Cecilia
AU - Kalergis, Alexis M.
AU - Riedel, Claudia A.
N1 - Publisher Copyright:
Copyright © 2023 Mendoza-León, Mangalam, Regaldiz, González-Madrid, Rangel-Ramírez, Álvarez-Mardonez, Vallejos, Méndez, Bueno, Melo-González, Duarte, Opazo, Kalergis and Riedel.
PY - 2023
Y1 - 2023
N2 - Thyroid disorders are clinically characterized by alterations of L-3,5,3’,5’-tetraiodothyronine (T4), L-3,5,3’-triiodothyronine (T3), and/or thyroid-stimulating hormone (TSH) levels in the blood. The most frequent thyroid disorders are hypothyroidism, hyperthyroidism, and hypothyroxinemia. These conditions affect cell differentiation, function, and metabolism. It has been reported that 40% of the world’s population suffers from some type of thyroid disorder and that several factors increase susceptibility to these diseases. Among them are iodine intake, environmental contamination, smoking, certain drugs, and genetic factors. Recently, the intestinal microbiota, composed of more than trillions of microbes, has emerged as a critical player in human health, and dysbiosis has been linked to thyroid diseases. The intestinal microbiota can affect host physiology by producing metabolites derived from dietary fiber, such as short-chain fatty acids (SCFAs). SCFAs have local actions in the intestine and can affect the central nervous system and immune system. Modulation of SCFAs-producing bacteria has also been connected to metabolic diseases, such as obesity and diabetes. In this review, we discuss how alterations in the production of SCFAs due to dysbiosis in patients could be related to thyroid disorders. The studies reviewed here may be of significant interest to endocrinology researchers and medical practitioners.
AB - Thyroid disorders are clinically characterized by alterations of L-3,5,3’,5’-tetraiodothyronine (T4), L-3,5,3’-triiodothyronine (T3), and/or thyroid-stimulating hormone (TSH) levels in the blood. The most frequent thyroid disorders are hypothyroidism, hyperthyroidism, and hypothyroxinemia. These conditions affect cell differentiation, function, and metabolism. It has been reported that 40% of the world’s population suffers from some type of thyroid disorder and that several factors increase susceptibility to these diseases. Among them are iodine intake, environmental contamination, smoking, certain drugs, and genetic factors. Recently, the intestinal microbiota, composed of more than trillions of microbes, has emerged as a critical player in human health, and dysbiosis has been linked to thyroid diseases. The intestinal microbiota can affect host physiology by producing metabolites derived from dietary fiber, such as short-chain fatty acids (SCFAs). SCFAs have local actions in the intestine and can affect the central nervous system and immune system. Modulation of SCFAs-producing bacteria has also been connected to metabolic diseases, such as obesity and diabetes. In this review, we discuss how alterations in the production of SCFAs due to dysbiosis in patients could be related to thyroid disorders. The studies reviewed here may be of significant interest to endocrinology researchers and medical practitioners.
KW - dysbiosis
KW - gut microbiota
KW - metabolic diseases
KW - metabolism and endocrinology
KW - Short-chain Fatty Acids (SCFAs)
KW - thyroid disorders
UR - http://www.scopus.com/inward/record.url?scp=85165012225&partnerID=8YFLogxK
U2 - 10.3389/fendo.2023.1192216
DO - 10.3389/fendo.2023.1192216
M3 - Review article
AN - SCOPUS:85165012225
SN - 1664-2392
VL - 14
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 1192216
ER -