TY - JOUR
T1 - Green ultrasound-assisted extraction of lichen substances from Hypotrachyna cirrhata. Ethyl lactate, a better extracting agent than methanol toxic organic solvent?
AU - Sepulveda, Beatriz
AU - Benites, Derin
AU - Albornoz, Laura
AU - Simirgiotis, Mario
AU - Castro, Olivio
AU - Garcia-Beltran, Olimpo
AU - Areche, Carlos
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/7/19
Y1 - 2021/7/19
N2 - For the first time, we report a green extraction of lichen substances assisted by high power ultrasounds from Hypotrachyna cirrhata using ethyl lactate. This sustainable alternative was comparable, both in isolation and detection of lichen substances, to methanol. In the metabolomic analysis, a total of 77 lichen substances were detected comprising depsides, depsidones, dibenzofurans, organic acids, and lipids. Although the UHPLC/ESI/MS profiles were similar, the antioxidant activity was higher for the ethyl lactate extract. Ethyl lactate can replace toxic organic solvents, such as methanol, in order to provide more sustainable green chemistry methods.
AB - For the first time, we report a green extraction of lichen substances assisted by high power ultrasounds from Hypotrachyna cirrhata using ethyl lactate. This sustainable alternative was comparable, both in isolation and detection of lichen substances, to methanol. In the metabolomic analysis, a total of 77 lichen substances were detected comprising depsides, depsidones, dibenzofurans, organic acids, and lipids. Although the UHPLC/ESI/MS profiles were similar, the antioxidant activity was higher for the ethyl lactate extract. Ethyl lactate can replace toxic organic solvents, such as methanol, in order to provide more sustainable green chemistry methods.
KW - alternative solvents
KW - antioxidants
KW - green chemistry
KW - Hypotrachyna
KW - LC/MS
KW - lichens
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85111709120&partnerID=8YFLogxK
U2 - 10.1080/14786419.2021.1956922
DO - 10.1080/14786419.2021.1956922
M3 - Article
AN - SCOPUS:85111709120
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
ER -