Glucocorticoid resistance in chronic diseases

Juan M. Rodriguez, Matías Monsalves-Alvarez, Sandra Henriquez, Miguel N. Llanos, Rodrigo Troncoso

Resultado de la investigación: Review article

30 Citas (Scopus)

Resumen

Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are extensively used to suppress allergic, inflammatory, and immune disorders. Although glucocorticoids are highly effective for therapeutic purposes, some patients chronically treated with glucocorticoids can develop reduced glucocorticoid sensitivity or even resistance, increasing patient vulnerability to exaggerated inflammatory responses. Glucocorticoid resistance can occur in several chronic diseases, including asthma, major depression, and cardiovascular conditions. In this review, we discuss the complexity of the glucocorticoid receptor and the potential role of glucocorticoid resistance in the development of chronic diseases.

Idioma originalEnglish
Páginas (desde-hasta)182-192
Número de páginas11
PublicaciónSteroids
Volumen115
DOI
EstadoPublished - 2016
Publicado de forma externa

Huella dactilar

Glucocorticoids
Chronic Disease
Immune System Diseases
Glucocorticoid Receptors
Asthma
Glucocorticoid Receptor Deficiency
Hormones
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Endocrinology
  • Clinical Biochemistry
  • Organic Chemistry

Citar esto

Rodriguez, J. M., Monsalves-Alvarez, M., Henriquez, S., Llanos, M. N., & Troncoso, R. (2016). Glucocorticoid resistance in chronic diseases. Steroids, 115, 182-192. https://doi.org/10.1016/j.steroids.2016.09.010
Rodriguez, Juan M. ; Monsalves-Alvarez, Matías ; Henriquez, Sandra ; Llanos, Miguel N. ; Troncoso, Rodrigo. / Glucocorticoid resistance in chronic diseases. En: Steroids. 2016 ; Vol. 115. pp. 182-192.
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Rodriguez, JM, Monsalves-Alvarez, M, Henriquez, S, Llanos, MN & Troncoso, R 2016, 'Glucocorticoid resistance in chronic diseases', Steroids, vol. 115, pp. 182-192. https://doi.org/10.1016/j.steroids.2016.09.010

Glucocorticoid resistance in chronic diseases. / Rodriguez, Juan M.; Monsalves-Alvarez, Matías; Henriquez, Sandra; Llanos, Miguel N.; Troncoso, Rodrigo.

En: Steroids, Vol. 115, 2016, p. 182-192.

Resultado de la investigación: Review article

TY - JOUR

T1 - Glucocorticoid resistance in chronic diseases

AU - Rodriguez, Juan M.

AU - Monsalves-Alvarez, Matías

AU - Henriquez, Sandra

AU - Llanos, Miguel N.

AU - Troncoso, Rodrigo

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Y1 - 2016

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AB - Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are extensively used to suppress allergic, inflammatory, and immune disorders. Although glucocorticoids are highly effective for therapeutic purposes, some patients chronically treated with glucocorticoids can develop reduced glucocorticoid sensitivity or even resistance, increasing patient vulnerability to exaggerated inflammatory responses. Glucocorticoid resistance can occur in several chronic diseases, including asthma, major depression, and cardiovascular conditions. In this review, we discuss the complexity of the glucocorticoid receptor and the potential role of glucocorticoid resistance in the development of chronic diseases.

KW - Corticosterone

KW - Cortisol

KW - Glucocorticoid receptor

KW - Inflammation

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Rodriguez JM, Monsalves-Alvarez M, Henriquez S, Llanos MN, Troncoso R. Glucocorticoid resistance in chronic diseases. Steroids. 2016;115:182-192. https://doi.org/10.1016/j.steroids.2016.09.010