Glucocorticoid resistance in chronic diseases

Juan M. Rodriguez, Matías Monsalves-Alvarez, Sandra Henriquez, Miguel N. Llanos, Rodrigo Troncoso

Resultado de la investigación: Contribución a una revistaArtículo de revisión

32 Citas (Scopus)

Resumen

Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are extensively used to suppress allergic, inflammatory, and immune disorders. Although glucocorticoids are highly effective for therapeutic purposes, some patients chronically treated with glucocorticoids can develop reduced glucocorticoid sensitivity or even resistance, increasing patient vulnerability to exaggerated inflammatory responses. Glucocorticoid resistance can occur in several chronic diseases, including asthma, major depression, and cardiovascular conditions. In this review, we discuss the complexity of the glucocorticoid receptor and the potential role of glucocorticoid resistance in the development of chronic diseases.

Idioma originalInglés
Páginas (desde-hasta)182-192
Número de páginas11
PublicaciónSteroids
Volumen115
DOI
EstadoPublicada - 2016
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Farmacología
  • Endocrinología
  • Bioquímica clínica
  • Química orgánica

Huella Profundice en los temas de investigación de 'Glucocorticoid resistance in chronic diseases'. En conjunto forman una huella única.

  • Citar esto

    Rodriguez, J. M., Monsalves-Alvarez, M., Henriquez, S., Llanos, M. N., & Troncoso, R. (2016). Glucocorticoid resistance in chronic diseases. Steroids, 115, 182-192. https://doi.org/10.1016/j.steroids.2016.09.010