Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Rodrigo Conlledo, Álvaro Rodríguez, Javiera Godoy, Carlos Merino, Felipe Martínez

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

Idioma originalSpanish
Páginas (desde-hasta)192-199
Número de páginas8
PublicaciónRevista Chilena de Infectologia
Volumen29
N.º2
DOI
EstadoPublished - 1 abr 2012

Huella dactilar

Globulins
Lymphocyte Count
Septic Shock
Sepsis
Mortality
ROC Curve
Area Under Curve
Intensive Care Units
Hospitalization
Cohort Studies
Prospective Studies
Lymphocytes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Citar esto

Conlledo, Rodrigo ; Rodríguez, Álvaro ; Godoy, Javiera ; Merino, Carlos ; Martínez, Felipe. / Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico. En: Revista Chilena de Infectologia. 2012 ; Vol. 29, N.º 2. pp. 192-199.
@article{3393167aac3a4786a79675d9d8618f9f,
title = "Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock s{\'e}ptico",
abstract = "Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95{\%} CI 0.53-0.82), with a sensitivity of 75{\%}, specifi city of 52{\%}, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95{\%} CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.",
keywords = "Lymphocytes count, Mortality, Septic shock, Serum globulins",
author = "Rodrigo Conlledo and {\'A}lvaro Rodr{\'i}guez and Javiera Godoy and Carlos Merino and Felipe Mart{\'i}nez",
year = "2012",
month = "4",
day = "1",
doi = "10.4067/S0716-10182012000200012",
language = "Spanish",
volume = "29",
pages = "192--199",
journal = "Revista Chilena de Infectologia",
issn = "0716-1018",
publisher = "Sociedad Chilena de Infectologia",
number = "2",

}

Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico. / Conlledo, Rodrigo; Rodríguez, Álvaro; Godoy, Javiera; Merino, Carlos; Martínez, Felipe.

En: Revista Chilena de Infectologia, Vol. 29, N.º 2, 01.04.2012, p. 192-199.

Resultado de la investigación: Article

TY - JOUR

T1 - Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

AU - Conlledo, Rodrigo

AU - Rodríguez, Álvaro

AU - Godoy, Javiera

AU - Merino, Carlos

AU - Martínez, Felipe

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

AB - Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

KW - Lymphocytes count

KW - Mortality

KW - Septic shock

KW - Serum globulins

UR - http://www.scopus.com/inward/record.url?scp=84861938132&partnerID=8YFLogxK

U2 - 10.4067/S0716-10182012000200012

DO - 10.4067/S0716-10182012000200012

M3 - Article

C2 - 22689035

AN - SCOPUS:84861938132

VL - 29

SP - 192

EP - 199

JO - Revista Chilena de Infectologia

JF - Revista Chilena de Infectologia

SN - 0716-1018

IS - 2

ER -