Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Rodrigo Conlledo, Álvaro Rodríguez, Javiera Godoy, Carlos Merino, Felipe Martínez

Resultado de la investigación: Contribución a una revistaArtículo

1 Cita (Scopus)

Resumen

Background: There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. Patients and Method: Prospective cohort study of 103 patients admitted in Intensive Care Unit followed daily at the Dr. Gustavo Fricke Hospital between June and November of 2009, with sepsis or septic shock criteria. Results: There was association between mortality and lymphocytic count measured from the third day of their hospitalization (P < 0.05), but not when compared with the plasmatic globulin measurements (P > 0.05). The area under ROC curve for the mean lymphocyte count at the third day was 0.68 (95% CI 0.53-0.82), with a sensitivity of 75%, specifi city of 52%, LR(+) 1.57 and LR(-) 0.48 for a cut-off at 510 lymphocytes/mm3, behaving also as an independent risk factor of mortality (OR 3.67, 95% CI 1.03-13.1). Discussion: Lymphocyte count is early and independently associated with increased mortality in patients with sepsis or septic shock.

Título traducido de la contribuciónTotal globulins and lymphocyte count as markers of mortality in sepsis and septic shock
Idioma originalEspañol
Páginas (desde-hasta)192-199
Número de páginas8
PublicaciónRevista Chilena de Infectologia
Volumen29
N.º2
DOI
EstadoPublicada - 1 abr 2012

Palabras clave

  • Lymphocytes count
  • Mortality
  • Septic shock
  • Serum globulins

Áreas temáticas de ASJC Scopus

  • Salud pública, medioambiental y laboral
  • Enfermedades infecciosas

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