Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD

Carlos A. Santiviago, Cecilia S. Toro, Alejandro A. Hidalgo, Philip Youderian, Guido C. Mora

Resultado de la investigación: Contribución a una revistaArtículo

40 Citas (Scopus)

Resumen

The OmpD porin is the most abundant outer membrane protein in Salmonella enterica serovar Typhimurium and represents about 1% of total cell protein. Unlike the case with the less abundant OmpC and OmpF porins, the stoichiometry of OmpD in the outer membrane does not change in response to changes in osmolarity. The abundance of OmpD increases in response to anaerobiosis and decreases in response to low pH, conditions encountered by serovar Typhimurium during the infection of its murine host. By constructing an operon fusion of the lacZY genes with the ompD promoter, we show that the abundance of OmpD in the outer membrane is regulated primarily at the level of transcription and is subject to catabolite repression. In response to anaerobiosis, the abundance of OmpD in the outer membrane also appears to be controlled posttranscriptionally by a function dependent on Fnr.

Idioma originalInglés
Páginas (desde-hasta)5901-5905
Número de páginas5
PublicaciónJournal of Bacteriology
Volumen185
N.º19
DOI
EstadoPublicada - oct 2003

Áreas temáticas de ASJC Scopus

  • Microbiología y biotecnología aplicadas
  • Inmunología
  • Microbiología
  • Biología molecular

Huella Profundice en los temas de investigación de 'Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD'. En conjunto forman una huella única.

  • Citar esto