Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD

Carlos A. Santiviago, Cecilia S. Toro, Alejandro A. Hidalgo, Philip Youderian, Guido C. Mora

Resultado de la investigación: Article

39 Citas (Scopus)

Resumen

The OmpD porin is the most abundant outer membrane protein in Salmonella enterica serovar Typhimurium and represents about 1% of total cell protein. Unlike the case with the less abundant OmpC and OmpF porins, the stoichiometry of OmpD in the outer membrane does not change in response to changes in osmolarity. The abundance of OmpD increases in response to anaerobiosis and decreases in response to low pH, conditions encountered by serovar Typhimurium during the infection of its murine host. By constructing an operon fusion of the lacZY genes with the ompD promoter, we show that the abundance of OmpD in the outer membrane is regulated primarily at the level of transcription and is subject to catabolite repression. In response to anaerobiosis, the abundance of OmpD in the outer membrane also appears to be controlled posttranscriptionally by a function dependent on Fnr.

Idioma originalEnglish
Páginas (desde-hasta)5901-5905
Número de páginas5
PublicaciónJournal of Bacteriology
Volumen185
N.º19
DOI
EstadoPublished - oct 2003

Huella dactilar

Porins
Salmonella enterica
Anaerobiosis
Membranes
Catabolite Repression
Gene Fusion
Operon
Osmolar Concentration
Membrane Proteins
Infection
Serogroup
Proteins

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Molecular Biology

Citar esto

Santiviago, Carlos A. ; Toro, Cecilia S. ; Hidalgo, Alejandro A. ; Youderian, Philip ; Mora, Guido C. / Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD. En: Journal of Bacteriology. 2003 ; Vol. 185, N.º 19. pp. 5901-5905.
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Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD. / Santiviago, Carlos A.; Toro, Cecilia S.; Hidalgo, Alejandro A.; Youderian, Philip; Mora, Guido C.

En: Journal of Bacteriology, Vol. 185, N.º 19, 10.2003, p. 5901-5905.

Resultado de la investigación: Article

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AU - Hidalgo, Alejandro A.

AU - Youderian, Philip

AU - Mora, Guido C.

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