Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array

Katharina Correa, Jean P. Lhorente, Liane Bassini, María E. López, Alex Di Genova, Alejandro Maass, William S. Davidson, José M. Yáñez

Resultado de la investigación: Article

26 Citas (Scopus)

Resumen

The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated. Sufficient additive genetic variation has been determined to include selection for resistance to this parasite in Atlantic salmon breeding programs. The aim of this study was to perform a Genome Wide Association Study in order to dissect the genetic factors involved in the resistance to C. rogercresseyi, one of the most important species of sea lice in the Chilean salmon farming. 2628 Atlantic salmon smolts, which had been experimentally infested with C. rogercresseyi, were genotyped using a 50K SNP array. Genome Wide Association Analysis was conducted using a polygenic model. A heritability of 0.12 for resistance to this louse species was estimated using genomic information. This result was consistent with estimates from previous studies which used pedigree records in the same population. Only one SNP, located on chromosome 21, was significant at a local level, explaining 0.5% of the phenotypic variance and 4% of the genomic heritability for sea lice resistance. This SNP is located in an intronic region of a predicted gene which codes for Collagen alpha-1. Our results suggest that resistance to C. rogercresseyi can be considered a polygenic trait, controlled by many variants of relatively small effect. Thus the incorporation of genomic information through genomic selection could be the most appropriate approach for breeding purposes. Statement of relevance Caligus resistance has a polygenic genetic architecture.

Idioma originalEnglish
Páginas (desde-hasta)61-65
Número de páginas5
PublicaciónAquaculture
Volumen472
DOI
EstadoPublished - 1 abr 2017

Huella dactilar

Caligus rogercresseyi
louse
Caligidae
Salmo salar
genotyping
genomics
genome
heritability
salmon
parasite
farming systems
breeding
Caligus
parasites
collagen
lice
smolt
smolts
chemical control
phenotypic variation

ASJC Scopus subject areas

  • Aquatic Science

Citar esto

Correa, Katharina ; Lhorente, Jean P. ; Bassini, Liane ; López, María E. ; Di Genova, Alex ; Maass, Alejandro ; Davidson, William S. ; Yáñez, José M. / Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array. En: Aquaculture. 2017 ; Vol. 472. pp. 61-65.
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title = "Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array",
abstract = "The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated. Sufficient additive genetic variation has been determined to include selection for resistance to this parasite in Atlantic salmon breeding programs. The aim of this study was to perform a Genome Wide Association Study in order to dissect the genetic factors involved in the resistance to C. rogercresseyi, one of the most important species of sea lice in the Chilean salmon farming. 2628 Atlantic salmon smolts, which had been experimentally infested with C. rogercresseyi, were genotyped using a 50K SNP array. Genome Wide Association Analysis was conducted using a polygenic model. A heritability of 0.12 for resistance to this louse species was estimated using genomic information. This result was consistent with estimates from previous studies which used pedigree records in the same population. Only one SNP, located on chromosome 21, was significant at a local level, explaining 0.5{\%} of the phenotypic variance and 4{\%} of the genomic heritability for sea lice resistance. This SNP is located in an intronic region of a predicted gene which codes for Collagen alpha-1. Our results suggest that resistance to C. rogercresseyi can be considered a polygenic trait, controlled by many variants of relatively small effect. Thus the incorporation of genomic information through genomic selection could be the most appropriate approach for breeding purposes. Statement of relevance Caligus resistance has a polygenic genetic architecture.",
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Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array. / Correa, Katharina; Lhorente, Jean P.; Bassini, Liane; López, María E.; Di Genova, Alex; Maass, Alejandro; Davidson, William S.; Yáñez, José M.

En: Aquaculture, Vol. 472, 01.04.2017, p. 61-65.

Resultado de la investigación: Article

TY - JOUR

T1 - Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array

AU - Correa, Katharina

AU - Lhorente, Jean P.

AU - Bassini, Liane

AU - López, María E.

AU - Di Genova, Alex

AU - Maass, Alejandro

AU - Davidson, William S.

AU - Yáñez, José M.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated. Sufficient additive genetic variation has been determined to include selection for resistance to this parasite in Atlantic salmon breeding programs. The aim of this study was to perform a Genome Wide Association Study in order to dissect the genetic factors involved in the resistance to C. rogercresseyi, one of the most important species of sea lice in the Chilean salmon farming. 2628 Atlantic salmon smolts, which had been experimentally infested with C. rogercresseyi, were genotyped using a 50K SNP array. Genome Wide Association Analysis was conducted using a polygenic model. A heritability of 0.12 for resistance to this louse species was estimated using genomic information. This result was consistent with estimates from previous studies which used pedigree records in the same population. Only one SNP, located on chromosome 21, was significant at a local level, explaining 0.5% of the phenotypic variance and 4% of the genomic heritability for sea lice resistance. This SNP is located in an intronic region of a predicted gene which codes for Collagen alpha-1. Our results suggest that resistance to C. rogercresseyi can be considered a polygenic trait, controlled by many variants of relatively small effect. Thus the incorporation of genomic information through genomic selection could be the most appropriate approach for breeding purposes. Statement of relevance Caligus resistance has a polygenic genetic architecture.

AB - The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated. Sufficient additive genetic variation has been determined to include selection for resistance to this parasite in Atlantic salmon breeding programs. The aim of this study was to perform a Genome Wide Association Study in order to dissect the genetic factors involved in the resistance to C. rogercresseyi, one of the most important species of sea lice in the Chilean salmon farming. 2628 Atlantic salmon smolts, which had been experimentally infested with C. rogercresseyi, were genotyped using a 50K SNP array. Genome Wide Association Analysis was conducted using a polygenic model. A heritability of 0.12 for resistance to this louse species was estimated using genomic information. This result was consistent with estimates from previous studies which used pedigree records in the same population. Only one SNP, located on chromosome 21, was significant at a local level, explaining 0.5% of the phenotypic variance and 4% of the genomic heritability for sea lice resistance. This SNP is located in an intronic region of a predicted gene which codes for Collagen alpha-1. Our results suggest that resistance to C. rogercresseyi can be considered a polygenic trait, controlled by many variants of relatively small effect. Thus the incorporation of genomic information through genomic selection could be the most appropriate approach for breeding purposes. Statement of relevance Caligus resistance has a polygenic genetic architecture.

KW - Atlantic salmon

KW - C. rogercresseyi

KW - Genome wide association study

KW - Pathogen resistance

KW - Sea lice

KW - Single nucleotide polymorphism

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U2 - 10.1016/j.aquaculture.2016.04.008

DO - 10.1016/j.aquaculture.2016.04.008

M3 - Article

VL - 472

SP - 61

EP - 65

JO - Aquaculture

JF - Aquaculture

SN - 0044-8486

ER -