Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population

Pia Villanueva, Dianne F. Newbury, Lilian Jara, Zulema De Barbieri, Ghazala Mirza, Hernán M. Palamino, María Angélica Fernández, Jean Baptiste Cazier, Anthony P. Monaco, Hernán Palomino

Resultado de la investigación: Article

31 Citas (Scopus)

Resumen

Specific language impairment (SLI) is an unexpected deficit in the acquisition of language skills and affects between 5 and 8% of pre-school children. Despite its prevalence and high heritability, our understanding of the aetiology of this disorder is only emerging. In this paper, we apply genome-wide techniques to investigate an isolated Chilean population who exhibit an increased frequency of SLI. Loss of heterozygosity (LOH) mapping and parametric and non-parametric linkage analyses indicate that complex genetic factors are likely to underlie susceptibility to SLI in this population. Across all analyses performed, the most consistently implicated locus was on chromosome 7q. This locus achieved highly significant linkage under all three non-parametric models (max NPL6.73, P4.0 × 10 11). In addition, it yielded a HLOD of 1.24 in the recessive parametric linkage analyses and contained a segment that was homozygous in two affected individuals. Further, investigation of this region identified a two-SNP haplotype that occurs at an increased frequency in language-impaired individuals (P0.008). We hypothesise that the linkage regions identified here, in particular that on chromosome 7, may contain variants that underlie the high prevalence of SLI observed in this isolated population and may be of relevance to other populations affected by language impairments.

Idioma originalEnglish
Páginas (desde-hasta)687-695
Número de páginas9
PublicaciónEuropean Journal of Human Genetics
Volumen19
N.º6
DOI
EstadoPublished - 1 jun 2011

Huella dactilar

Genetic Predisposition to Disease
Language
Genome
Population
Chromosomes, Human, Pair 7
Loss of Heterozygosity
Haplotypes
Single Nucleotide Polymorphism
Chromosomes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Citar esto

Villanueva, Pia ; Newbury, Dianne F. ; Jara, Lilian ; De Barbieri, Zulema ; Mirza, Ghazala ; Palamino, Hernán M. ; Fernández, María Angélica ; Cazier, Jean Baptiste ; Monaco, Anthony P. ; Palomino, Hernán. / Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population. En: European Journal of Human Genetics. 2011 ; Vol. 19, N.º 6. pp. 687-695.
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abstract = "Specific language impairment (SLI) is an unexpected deficit in the acquisition of language skills and affects between 5 and 8{\%} of pre-school children. Despite its prevalence and high heritability, our understanding of the aetiology of this disorder is only emerging. In this paper, we apply genome-wide techniques to investigate an isolated Chilean population who exhibit an increased frequency of SLI. Loss of heterozygosity (LOH) mapping and parametric and non-parametric linkage analyses indicate that complex genetic factors are likely to underlie susceptibility to SLI in this population. Across all analyses performed, the most consistently implicated locus was on chromosome 7q. This locus achieved highly significant linkage under all three non-parametric models (max NPL6.73, P4.0 × 10 11). In addition, it yielded a HLOD of 1.24 in the recessive parametric linkage analyses and contained a segment that was homozygous in two affected individuals. Further, investigation of this region identified a two-SNP haplotype that occurs at an increased frequency in language-impaired individuals (P0.008). We hypothesise that the linkage regions identified here, in particular that on chromosome 7, may contain variants that underlie the high prevalence of SLI observed in this isolated population and may be of relevance to other populations affected by language impairments.",
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Villanueva, P, Newbury, DF, Jara, L, De Barbieri, Z, Mirza, G, Palamino, HM, Fernández, MA, Cazier, JB, Monaco, AP & Palomino, H 2011, 'Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population', European Journal of Human Genetics, vol. 19, n.º 6, pp. 687-695. https://doi.org/10.1038/ejhg.2010.251

Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population. / Villanueva, Pia; Newbury, Dianne F.; Jara, Lilian; De Barbieri, Zulema; Mirza, Ghazala; Palamino, Hernán M.; Fernández, María Angélica; Cazier, Jean Baptiste; Monaco, Anthony P.; Palomino, Hernán.

En: European Journal of Human Genetics, Vol. 19, N.º 6, 01.06.2011, p. 687-695.

Resultado de la investigación: Article

TY - JOUR

T1 - Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population

AU - Villanueva, Pia

AU - Newbury, Dianne F.

AU - Jara, Lilian

AU - De Barbieri, Zulema

AU - Mirza, Ghazala

AU - Palamino, Hernán M.

AU - Fernández, María Angélica

AU - Cazier, Jean Baptiste

AU - Monaco, Anthony P.

AU - Palomino, Hernán

PY - 2011/6/1

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N2 - Specific language impairment (SLI) is an unexpected deficit in the acquisition of language skills and affects between 5 and 8% of pre-school children. Despite its prevalence and high heritability, our understanding of the aetiology of this disorder is only emerging. In this paper, we apply genome-wide techniques to investigate an isolated Chilean population who exhibit an increased frequency of SLI. Loss of heterozygosity (LOH) mapping and parametric and non-parametric linkage analyses indicate that complex genetic factors are likely to underlie susceptibility to SLI in this population. Across all analyses performed, the most consistently implicated locus was on chromosome 7q. This locus achieved highly significant linkage under all three non-parametric models (max NPL6.73, P4.0 × 10 11). In addition, it yielded a HLOD of 1.24 in the recessive parametric linkage analyses and contained a segment that was homozygous in two affected individuals. Further, investigation of this region identified a two-SNP haplotype that occurs at an increased frequency in language-impaired individuals (P0.008). We hypothesise that the linkage regions identified here, in particular that on chromosome 7, may contain variants that underlie the high prevalence of SLI observed in this isolated population and may be of relevance to other populations affected by language impairments.

AB - Specific language impairment (SLI) is an unexpected deficit in the acquisition of language skills and affects between 5 and 8% of pre-school children. Despite its prevalence and high heritability, our understanding of the aetiology of this disorder is only emerging. In this paper, we apply genome-wide techniques to investigate an isolated Chilean population who exhibit an increased frequency of SLI. Loss of heterozygosity (LOH) mapping and parametric and non-parametric linkage analyses indicate that complex genetic factors are likely to underlie susceptibility to SLI in this population. Across all analyses performed, the most consistently implicated locus was on chromosome 7q. This locus achieved highly significant linkage under all three non-parametric models (max NPL6.73, P4.0 × 10 11). In addition, it yielded a HLOD of 1.24 in the recessive parametric linkage analyses and contained a segment that was homozygous in two affected individuals. Further, investigation of this region identified a two-SNP haplotype that occurs at an increased frequency in language-impaired individuals (P0.008). We hypothesise that the linkage regions identified here, in particular that on chromosome 7, may contain variants that underlie the high prevalence of SLI observed in this isolated population and may be of relevance to other populations affected by language impairments.

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