TY - CHAP
T1 - Genetic and epigenetic control of the regulatory machinery for skeletal development and bone formation
T2 - Contributions of vitamin D3
AU - Lian, Jane B.
AU - Stein, Gary S.
AU - Montecino, Martin
AU - Stein, Janet L.
AU - Van Wijnen, Andre J.
N1 - Funding Information:
Results presented in this chapter were in part supported by National Institutes of Health grants R37DE012528, R37DE012528-S1, R01AR039588, PO1AR048818, R01AR049069, FONDECYT 1095075, and T32DK007302, as well as Core resources supported by the Diabetes Endocrinology Research Center grant DK32520 from the National Institute of Diabetes and Digestive and Kidney Diseases. Gary Stein, Janet Stein, and Jane Lian are members of the UMass DERC (DK32520). The contents of this chapter are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
PY - 2011
Y1 - 2011
N2 - The structural and metabolic functions of bone tissue arise from its unique properties as a mineralized connective tissue. This chapter begins with a brief review of bone architecture and the interactions of functionally distinct cells. This crosstalk mediates competency for bone to respond to the physiologic signals that include the calcitrophic hormone axis, developmental osteogenic factors, secreted cytokines, and bone-specific transcription factors. Following this, it throws light on recent concepts that have identified the functional relationships between gene expression and nuclear structure in organizing the regulatory information for gene expression. Following this, it evaluates the impact of epigenetic modifications of genes that control cell fate and lineage-specific phenotypes through association of transcriptional regulators with target gene loci on mitotic chromosomes. Furthermore, it explains the chromatin modifications in transcriptionally active and repressed genes that are selectively influenced by Runx2 and the vitamin D receptor (VDR) complex to regulate the stage-specific expression of genes that mediate progression of osteoblast proliferation and differentiation. The dynamic integration of developmental signaling pathways and the unique genetic and epigenetic transcriptional regulators of cell growth and differentiation that coordinate skeletogenesis and the control of bone remodeling provide new dimensions for improving diagnosis and treatment of skeletal diseases.
AB - The structural and metabolic functions of bone tissue arise from its unique properties as a mineralized connective tissue. This chapter begins with a brief review of bone architecture and the interactions of functionally distinct cells. This crosstalk mediates competency for bone to respond to the physiologic signals that include the calcitrophic hormone axis, developmental osteogenic factors, secreted cytokines, and bone-specific transcription factors. Following this, it throws light on recent concepts that have identified the functional relationships between gene expression and nuclear structure in organizing the regulatory information for gene expression. Following this, it evaluates the impact of epigenetic modifications of genes that control cell fate and lineage-specific phenotypes through association of transcriptional regulators with target gene loci on mitotic chromosomes. Furthermore, it explains the chromatin modifications in transcriptionally active and repressed genes that are selectively influenced by Runx2 and the vitamin D receptor (VDR) complex to regulate the stage-specific expression of genes that mediate progression of osteoblast proliferation and differentiation. The dynamic integration of developmental signaling pathways and the unique genetic and epigenetic transcriptional regulators of cell growth and differentiation that coordinate skeletogenesis and the control of bone remodeling provide new dimensions for improving diagnosis and treatment of skeletal diseases.
UR - http://www.scopus.com/inward/record.url?scp=84873995776&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-381978-9.10016-2
DO - 10.1016/B978-0-12-381978-9.10016-2
M3 - Chapter
AN - SCOPUS:84873995776
SN - 9780123819789
SP - 301
EP - 319
BT - Vitamin D
PB - Elsevier Inc.
ER -