Gastroprotective activity of epitaondiol and sargaol

Carlos Areche, Aurelio San-Martín, Juana Rovirosa, Beatriz Sepúlveda

Resultado de la investigación: Article

8 Citas (Scopus)

Resumen

The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED 50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.

Idioma originalEnglish
Páginas (desde-hasta)1073-1074
Número de páginas2
PublicaciónNatural Product Communications
Volumen6
N.º8
EstadoPublished - 10 nov 2011

Huella dactilar

lesions (animal)
stomach
Lansoprazole
Phaeophyceae
gastric mucosa
mice
Stomach
animal models
ethanol
Phaeophyta
dosage
Gastric Mucosa
Ethanol
lansoprazole
sargaol
epitaondiol
Stypopodium flabelliforme

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Citar esto

Areche, C., San-Martín, A., Rovirosa, J., & Sepúlveda, B. (2011). Gastroprotective activity of epitaondiol and sargaol. Natural Product Communications, 6(8), 1073-1074.
Areche, Carlos ; San-Martín, Aurelio ; Rovirosa, Juana ; Sepúlveda, Beatriz. / Gastroprotective activity of epitaondiol and sargaol. En: Natural Product Communications. 2011 ; Vol. 6, N.º 8. pp. 1073-1074.
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Areche, C, San-Martín, A, Rovirosa, J & Sepúlveda, B 2011, 'Gastroprotective activity of epitaondiol and sargaol', Natural Product Communications, vol. 6, n.º 8, pp. 1073-1074.

Gastroprotective activity of epitaondiol and sargaol. / Areche, Carlos; San-Martín, Aurelio; Rovirosa, Juana; Sepúlveda, Beatriz.

En: Natural Product Communications, Vol. 6, N.º 8, 10.11.2011, p. 1073-1074.

Resultado de la investigación: Article

TY - JOUR

T1 - Gastroprotective activity of epitaondiol and sargaol

AU - Areche, Carlos

AU - San-Martín, Aurelio

AU - Rovirosa, Juana

AU - Sepúlveda, Beatriz

PY - 2011/11/10

Y1 - 2011/11/10

N2 - The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED 50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.

AB - The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED 50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.

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KW - Gastroprotective activity

KW - Sargaol

KW - Stypopodium flabelliforme

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Areche C, San-Martín A, Rovirosa J, Sepúlveda B. Gastroprotective activity of epitaondiol and sargaol. Natural Product Communications. 2011 nov 10;6(8):1073-1074.