Functional interrelationships between nuclear structure and transcriptional control: Contributions to regulation of cell cycle- and tissue- specific gene expression

Gary S. Stein, Janet L. Stein, Jane B. Lian, André J. Van Wijnen, Martin Montecino

Resultado de la investigación: Review article

34 Citas (Scopus)

Resumen

Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue- specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.

Idioma originalEnglish
Páginas (desde-hasta)198-209
Número de páginas12
PublicaciónJournal of Cellular Biochemistry
Volumen62
N.º2
DOI
EstadoPublished - 1996

Huella dactilar

Gene expression
Cell Cycle
Genes
Cells
Tissue
Gene Expression
Nuclear Matrix
Nucleosomes
Regulator Genes
Chromatin
Transcription Factors

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Citar esto

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abstract = "Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue- specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.",
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Functional interrelationships between nuclear structure and transcriptional control : Contributions to regulation of cell cycle- and tissue- specific gene expression. / Stein, Gary S.; Stein, Janet L.; Lian, Jane B.; Van Wijnen, André J.; Montecino, Martin.

En: Journal of Cellular Biochemistry, Vol. 62, N.º 2, 1996, p. 198-209.

Resultado de la investigación: Review article

TY - JOUR

T1 - Functional interrelationships between nuclear structure and transcriptional control

T2 - Contributions to regulation of cell cycle- and tissue- specific gene expression

AU - Stein, Gary S.

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - Van Wijnen, André J.

AU - Montecino, Martin

PY - 1996

Y1 - 1996

N2 - Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue- specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.

AB - Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue- specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.

KW - cell cycle

KW - gene regulatory sequences

KW - nuclear structure

KW - tissue-related signals

KW - transcriptional control

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