Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair

Gary S. Stein, Sayyed K. Zaidi, Corey D. Braastad, Martin Montecino, Andre J. Van Wijnen, Je Yong Choi, Janet L. Stein, Jane B. Lian, Amjad Javed

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

108 Citas (Scopus)

Resumen

The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.

Idioma originalInglés
Páginas (desde-hasta)584-592
Número de páginas9
PublicaciónTrends in Cell Biology
Volumen13
N.º11
DOI
EstadoPublicada - nov. 2003

Áreas temáticas de ASJC Scopus

  • Biología celular

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