TY - JOUR
T1 - Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
AU - Melo-Gonzalez, Felipe
AU - Hepworth, Matthew R.
N1 - Publisher Copyright:
© 2016 The Authors. Immunology published by John Wiley & Sons Ltd.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid-related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi-like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever-expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.
AB - Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid-related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi-like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever-expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.
KW - group 3 innate lymphoid cells
KW - innate lymphoid cell
KW - lymphoid tissue-inducer cells
KW - mucosal immunology
UR - http://www.scopus.com/inward/record.url?scp=85007529996&partnerID=8YFLogxK
U2 - 10.1111/imm.12697
DO - 10.1111/imm.12697
M3 - Review article
C2 - 27935637
AN - SCOPUS:85007529996
SN - 0019-2805
VL - 150
SP - 265
EP - 275
JO - Immunology
JF - Immunology
IS - 3
ER -