Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

Felipe Melo-Gonzalez, Matthew R. Hepworth

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

139 Citas (Scopus)

Resumen

Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid-related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi-like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever-expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.

Idioma originalInglés
Páginas (desde-hasta)265-275
Número de páginas11
PublicaciónImmunology
Volumen150
N.º3
DOI
EstadoPublicada - 1 mar. 2017
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología

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