Fructose and prostate cancer: toward an integrated view of cancer cell metabolism

Daniela Carreño, Néstor Corro, Verónica Torres-Estay, Loreto P. Véliz, Rodrigo Jaimovich, Pedro Cisternas, Ignacio F. San Francisco, Paula C. Sotomayor, Marina Tanasova, Nibaldo C. Inestrosa, Alejandro S. Godoy

Resultado de la investigación: Article

Resumen

Activation of glucose transporter-1 (Glut-1) gene expression is a molecular feature of cancer cells that increases glucose uptake and metabolism. Increased glucose uptake is the basis for the clinical localization of primary tumors using positron emission tomography (PET) and 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) as a radiotracer. However, previous studies have demonstrated that a considerable number of cancers, which include prostate cancer (CaP), express low to undetectable levels of Glut-1 and that FDG-PET has limited clinical applicability in CaP. This observation could be explained by a low metabolic activity of CaP cells that may be overcome using different hexoses, such as fructose, as the preferred energy source. However, these hypotheses have not been examined critically in CaP. This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo. Moreover, this review highlights recent findings that allow better understanding of how metabolism of fructose may regulate cancer cell proliferation and how fructose uptake and metabolism, through the de novo lipogenesis pathway, may provide new opportunities for CaP early diagnosis, staging, and treatment.

Idioma originalEnglish
PublicaciónProstate Cancer and Prostatic Diseases
DOI
EstadoAccepted/In press - 1 ene 2018

Huella dactilar

Fructose
Prostatic Neoplasms
Hexoses
Facilitative Glucose Transport Proteins
Neoplasms
Glucose
Positron-Emission Tomography
Lipogenesis
Early Diagnosis
Cell Proliferation
Gene Expression

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Citar esto

Carreño, D., Corro, N., Torres-Estay, V., Véliz, L. P., Jaimovich, R., Cisternas, P., ... Godoy, A. S. (Aceptado/En prensa). Fructose and prostate cancer: toward an integrated view of cancer cell metabolism. Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-018-0072-7
Carreño, Daniela ; Corro, Néstor ; Torres-Estay, Verónica ; Véliz, Loreto P. ; Jaimovich, Rodrigo ; Cisternas, Pedro ; San Francisco, Ignacio F. ; Sotomayor, Paula C. ; Tanasova, Marina ; Inestrosa, Nibaldo C. ; Godoy, Alejandro S. / Fructose and prostate cancer : toward an integrated view of cancer cell metabolism. En: Prostate Cancer and Prostatic Diseases. 2018.
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abstract = "Activation of glucose transporter-1 (Glut-1) gene expression is a molecular feature of cancer cells that increases glucose uptake and metabolism. Increased glucose uptake is the basis for the clinical localization of primary tumors using positron emission tomography (PET) and 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) as a radiotracer. However, previous studies have demonstrated that a considerable number of cancers, which include prostate cancer (CaP), express low to undetectable levels of Glut-1 and that FDG-PET has limited clinical applicability in CaP. This observation could be explained by a low metabolic activity of CaP cells that may be overcome using different hexoses, such as fructose, as the preferred energy source. However, these hypotheses have not been examined critically in CaP. This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo. Moreover, this review highlights recent findings that allow better understanding of how metabolism of fructose may regulate cancer cell proliferation and how fructose uptake and metabolism, through the de novo lipogenesis pathway, may provide new opportunities for CaP early diagnosis, staging, and treatment.",
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Carreño, D, Corro, N, Torres-Estay, V, Véliz, LP, Jaimovich, R, Cisternas, P, San Francisco, IF, Sotomayor, PC, Tanasova, M, Inestrosa, NC & Godoy, AS 2018, 'Fructose and prostate cancer: toward an integrated view of cancer cell metabolism', Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-018-0072-7

Fructose and prostate cancer : toward an integrated view of cancer cell metabolism. / Carreño, Daniela; Corro, Néstor; Torres-Estay, Verónica; Véliz, Loreto P.; Jaimovich, Rodrigo; Cisternas, Pedro; San Francisco, Ignacio F.; Sotomayor, Paula C.; Tanasova, Marina; Inestrosa, Nibaldo C.; Godoy, Alejandro S.

En: Prostate Cancer and Prostatic Diseases, 01.01.2018.

Resultado de la investigación: Article

TY - JOUR

T1 - Fructose and prostate cancer

T2 - toward an integrated view of cancer cell metabolism

AU - Carreño, Daniela

AU - Corro, Néstor

AU - Torres-Estay, Verónica

AU - Véliz, Loreto P.

AU - Jaimovich, Rodrigo

AU - Cisternas, Pedro

AU - San Francisco, Ignacio F.

AU - Sotomayor, Paula C.

AU - Tanasova, Marina

AU - Inestrosa, Nibaldo C.

AU - Godoy, Alejandro S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Activation of glucose transporter-1 (Glut-1) gene expression is a molecular feature of cancer cells that increases glucose uptake and metabolism. Increased glucose uptake is the basis for the clinical localization of primary tumors using positron emission tomography (PET) and 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) as a radiotracer. However, previous studies have demonstrated that a considerable number of cancers, which include prostate cancer (CaP), express low to undetectable levels of Glut-1 and that FDG-PET has limited clinical applicability in CaP. This observation could be explained by a low metabolic activity of CaP cells that may be overcome using different hexoses, such as fructose, as the preferred energy source. However, these hypotheses have not been examined critically in CaP. This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo. Moreover, this review highlights recent findings that allow better understanding of how metabolism of fructose may regulate cancer cell proliferation and how fructose uptake and metabolism, through the de novo lipogenesis pathway, may provide new opportunities for CaP early diagnosis, staging, and treatment.

AB - Activation of glucose transporter-1 (Glut-1) gene expression is a molecular feature of cancer cells that increases glucose uptake and metabolism. Increased glucose uptake is the basis for the clinical localization of primary tumors using positron emission tomography (PET) and 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) as a radiotracer. However, previous studies have demonstrated that a considerable number of cancers, which include prostate cancer (CaP), express low to undetectable levels of Glut-1 and that FDG-PET has limited clinical applicability in CaP. This observation could be explained by a low metabolic activity of CaP cells that may be overcome using different hexoses, such as fructose, as the preferred energy source. However, these hypotheses have not been examined critically in CaP. This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo. Moreover, this review highlights recent findings that allow better understanding of how metabolism of fructose may regulate cancer cell proliferation and how fructose uptake and metabolism, through the de novo lipogenesis pathway, may provide new opportunities for CaP early diagnosis, staging, and treatment.

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DO - 10.1038/s41391-018-0072-7

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