From Concentrated Dispersion to Solid β-Cyclodextrin Polymer-Capped Silver Nanoparticle Formulation: A Trojan Horse Against Escherichia coli

Rudy Martin-Trasanco, Giovanna Anziani-Ostuni, Hilda Esperanza Esparza-Ponce, Pedro Ortiz, María E. Montero-Cabrera, Diego P. Oyarzún, César Zúñiga, José Manuel Pérez-Donoso, Guadalupe del C. Pizarro, Ramiro Arratia-Pérez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Preparation of concentrated silver nanoparticles in water remains a challenge today. The intrinsic reactivity of silver, as well as the high surface energy of nanoparticles, make it difficult to handle them without altering their pristine properties. Herein, we report the preparation of concentrated silver nanoparticles (AgNPs) dispersion (2 mM; 1.5⋅1015 NPs/mL) by reducing Ag+ in-situ of a β-cyclodextrin-epichlorohydrin polymer (βCDP) as a capping agent. The prepared nanoparticles ([email protected]βCDP) with a Surface Plasmon Resonance band at 396 nm, and a hydrodynamic diameter of 21.4 ±1.8 nm, retained both features after being precipitated and re-dispersed in water. The AgNPs core had a spherical morphology, with a 12.7 ±1.5 nm diameter in size, as determined by TEM. The [email protected]βCDP showed outstanding bactericidal properties against Escherichia coli (MIC= 0.37 nM), one of the lowest ever achieved for silver nanoparticles. We suggest that the polymer acts as a Trojan horse with AgNPs as payload.

Idioma originalInglés
Páginas (desde-hasta)10092-10096
Número de páginas5
PublicaciónChemistrySelect
Volumen4
N.º34
DOI
EstadoPublicada - 13 sep 2019

Áreas temáticas de ASJC Scopus

  • Química (todo)

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