Extracellular cysteine in connexins: Role as redox sensors

Mauricio A. Retamal, Isaac E. García, Bernardo I. Pinto, Amaury Pupo, David Báez, Jimmy Stehberg, Rodrigo Del Rio, Carlos González

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression.

Idioma originalInglés
Número de artículo1
PublicaciónFrontiers in Physiology
Volumen7
N.ºJAN
DOI
EstadoPublicada - 28 ene 2016

Áreas temáticas de ASJC Scopus

  • Fisiología
  • Fisiología (médica)

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