Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru

J. A. Benavides, C. Shiva, M. Virhuez, C. Tello, A. Appelgren, J. Vendrell, J. Solassol, S. Godreuil, D. G. Streicker

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Antibiotic resistance mediated by bacterial production of extended-spectrum beta-lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital-acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL-producing bacteria. Only limited data are available on the circulation of ESBL-producing bacteria in animals. Here, we report ESBL-producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of blaCTX-M-15 genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E. coli strains carrying this resistance that were not always host species-specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic-resistant strains of public health importance and to understand the origin of the observed resistance.

Idioma originalEnglish
Páginas (desde-hasta)454-458
Número de páginas5
PublicaciónZoonoses and Public Health
Volumen65
N.º4
DOI
EstadoPublished - 1 jun 2018

Huella dactilar

Desmodus
Peru
beta-lactamase
Livestock
beta-Lactamases
Chiroptera
livestock
Escherichia coli
public health
Public Health
Bacterial Drug Resistance
Bacteria
Multilocus Sequence Typing
cross infection
Wild Animals
bacteria
Domestic Animals
Zoonoses
wild animals
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Immunology
  • Microbiology

Citar esto

Benavides, J. A. ; Shiva, C. ; Virhuez, M. ; Tello, C. ; Appelgren, A. ; Vendrell, J. ; Solassol, J. ; Godreuil, S. ; Streicker, D. G. / Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru. En: Zoonoses and Public Health. 2018 ; Vol. 65, N.º 4. pp. 454-458.
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title = "Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru",
abstract = "Antibiotic resistance mediated by bacterial production of extended-spectrum beta-lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital-acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL-producing bacteria. Only limited data are available on the circulation of ESBL-producing bacteria in animals. Here, we report ESBL-producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of blaCTX-M-15 genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E. coli strains carrying this resistance that were not always host species-specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic-resistant strains of public health importance and to understand the origin of the observed resistance.",
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Benavides, JA, Shiva, C, Virhuez, M, Tello, C, Appelgren, A, Vendrell, J, Solassol, J, Godreuil, S & Streicker, DG 2018, 'Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru', Zoonoses and Public Health, vol. 65, n.º 4, pp. 454-458. https://doi.org/10.1111/zph.12456

Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru. / Benavides, J. A.; Shiva, C.; Virhuez, M.; Tello, C.; Appelgren, A.; Vendrell, J.; Solassol, J.; Godreuil, S.; Streicker, D. G.

En: Zoonoses and Public Health, Vol. 65, N.º 4, 01.06.2018, p. 454-458.

Resultado de la investigación: Article

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AU - Benavides, J. A.

AU - Shiva, C.

AU - Virhuez, M.

AU - Tello, C.

AU - Appelgren, A.

AU - Vendrell, J.

AU - Solassol, J.

AU - Godreuil, S.

AU - Streicker, D. G.

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