Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae

Kevin Maisey, Gino Nardocci, Monica Imarai, Hugo Cardenas, Miguel Rios, Horacio B. Croxatto, John E. Heckels, Myron Christodoulides, Luis A. Velasquez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

43 Citas (Scopus)

Resumen

Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae can lead to acute salpingitis, an inflammatory condition, which is a major cause of infertility. Challenge of explants of human FT with gonococci induced mRNA expression and protein secretion for the proinflammatory cytokines interleukin (IL)-1α, IL-1β, and tumor necrosis factor alpha (TNF-α) but not for granulocyte-macrophage colony-stimulating factor. In contrast, FT expression of IL-6 and of the cytokine receptors IL-6R, TNF receptor I (TNF-RI), and TNF-RII was constitutive and was not increased by gonococcal challenge. These studies suggest that several proinflammatory cytokines are likely to contribute to the cell and tissue damage observed in gonococcal salpingitis.

Idioma originalInglés
Páginas (desde-hasta)527-532
Número de páginas6
PublicaciónInfection and Immunity
Volumen71
N.º1
DOI
EstadoPublicada - 1 ene 2003

Áreas temáticas de ASJC Scopus

  • Parasitología
  • Microbiología
  • Inmunología
  • Enfermedades infecciosas

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