We present the results of the analysis of our recent inter-ferometric observations of Betelgeuse, using the AMBER instrument of the VLTI. Using the medium spectral resolution mode (R ∼ 1500) we detected the presence of the water vapour and carbon monoxide (CO) molecules in the H and K bands. We also derived the photo-spheric angular diameter in the continuum. By analysing the depth of the molecular lines and the interferometric visibilities, we derived the column densities of the molecules, as well as the temperature and the size of the corresponding regions in the atmosphere of Betelgeuse (the MOLsphere) using a single shell model around the photosphere. Our results confirm the findings by Perrin et al. (2004) and Ohnaka et al. (2011) that the H 2O and CO molecules are distributed around Betelgeuse in a MOLsphere extending to approximately 1.3 times the star's photospheric radius.