Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

A. Fonseca, M. J. Matos, J. Reis, Y. Duarte, M. Gutiérrez, L. Santana, E. Uriarte, F. Borges

Resultado de la investigación: Contribución a una revistaArtículo

9 Citas (Scopus)

Resumen

Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.

Idioma originalInglés
Páginas (desde-hasta)49764-49768
Número de páginas5
PublicaciónRSC Advances
Volumen6
N.º55
DOI
EstadoPublicada - 1 ene 2016

Áreas temáticas de ASJC Scopus

  • Química (todo)
  • Ingeniería química (todo)

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  • Citar esto

    Fonseca, A., Matos, M. J., Reis, J., Duarte, Y., Gutiérrez, M., Santana, L., Uriarte, E., & Borges, F. (2016). Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. RSC Advances, 6(55), 49764-49768. https://doi.org/10.1039/c6ra05262b