Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

A. Fonseca; M. J. Matos; J. Reis; Y. Duarte; M. Gutiérrez; L. Santana; E. Uriarte; F. Borges

doi:10.1039/c6ra05262b

Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

A. Fonseca, M. J. Matos, J. Reis, Y. Duarte, M. Gutiérrez, L. Santana, E. Uriarte, F. Borges

Facultad de Ciencias de la Vida

Resultado de la investigación: Contribución a una revista › Artículo

9 Citas (Scopus)

Resumen

Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC₅₀hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.

Idioma original	Inglés
Páginas (desde-hasta)	49764-49768
Número de páginas	5
Publicación	RSC Advances
Volumen	6
N.º	55
DOI	https://doi.org/10.1039/c6ra05262b
Estado	Publicada - 1 ene 2016

Áreas temáticas de ASJC Scopus

Química (todo)
Ingeniería química (todo)

Acceder al documento

10.1039/c6ra05262b

Link to publication in Scopus

Huella Profundice en los temas de investigación de 'Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold'. En conjunto forman una huella única.

Citar esto

Fonseca, A., Matos, M. J., Reis, J., Duarte, Y., Gutiérrez, M., Santana, L., Uriarte, E., & Borges, F. (2016). Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. RSC Advances, 6(55), 49764-49768. https://doi.org/10.1039/c6ra05262b

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AU - Uriarte, E.

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