Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

A. Fonseca, M. J. Matos, J. Reis, Y. Duarte, M. Gutiérrez, L. Santana, E. Uriarte, F. Borges

Resultado de la investigación: Article

9 Citas (Scopus)

Resumen

Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.

Idioma originalEnglish
Páginas (desde-hasta)49764-49768
Número de páginas5
PublicaciónRSC Advances
Volumen6
N.º55
DOI
EstadoPublished - 1 ene 2016

Huella dactilar

Monoamine Oxidase
Scaffolds
Enzymes
coumarin

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Citar esto

Fonseca, A. ; Matos, M. J. ; Reis, J. ; Duarte, Y. ; Gutiérrez, M. ; Santana, L. ; Uriarte, E. ; Borges, F. / Exploring coumarin potentialities : Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. En: RSC Advances. 2016 ; Vol. 6, N.º 55. pp. 49764-49768.
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Fonseca, A, Matos, MJ, Reis, J, Duarte, Y, Gutiérrez, M, Santana, L, Uriarte, E & Borges, F 2016, 'Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold', RSC Advances, vol. 6, n.º 55, pp. 49764-49768. https://doi.org/10.1039/c6ra05262b

Exploring coumarin potentialities : Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. / Fonseca, A.; Matos, M. J.; Reis, J.; Duarte, Y.; Gutiérrez, M.; Santana, L.; Uriarte, E.; Borges, F.

En: RSC Advances, Vol. 6, N.º 55, 01.01.2016, p. 49764-49768.

Resultado de la investigación: Article

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AU - Santana, L.

AU - Uriarte, E.

AU - Borges, F.

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