Resumen
Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 49764-49768 |
| Número de páginas | 5 |
| Publicación | RSC Advances |
| Volumen | 6 |
| N.º | 55 |
| DOI | |
| Estado | Published - 1 ene 2016 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
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Exploring coumarin potentialities : Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold. / Fonseca, A.; Matos, M. J.; Reis, J.; Duarte, Y.; Gutiérrez, M.; Santana, L.; Uriarte, E.; Borges, F.
En: RSC Advances, Vol. 6, N.º 55, 01.01.2016, p. 49764-49768.Resultado de la investigación: Article
TY - JOUR
T1 - Exploring coumarin potentialities
T2 - Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold
AU - Fonseca, A.
AU - Matos, M. J.
AU - Reis, J.
AU - Duarte, Y.
AU - Gutiérrez, M.
AU - Santana, L.
AU - Uriarte, E.
AU - Borges, F.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.
AB - Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.
UR - http://www.scopus.com/inward/record.url?scp=84973562593&partnerID=8YFLogxK
U2 - 10.1039/c6ra05262b
DO - 10.1039/c6ra05262b
M3 - Article
AN - SCOPUS:84973562593
VL - 6
SP - 49764
EP - 49768
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 55
ER -