Resumen
Novel 6-methyl-3-carboxamidocoumarins (compounds 4-15) were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes. In general, the compounds act as selective MAO-B inhibitors. Compound 11 is highlighted as a potent (IC50hMAO-B = 4.66 nM), reversible and non-competitive MAO-B inhibitor.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 49764-49768 |
Número de páginas | 5 |
Publicación | RSC Advances |
Volumen | 6 |
N.º | 55 |
DOI | |
Estado | Publicada - 1 ene. 2016 |
Áreas temáticas de ASJC Scopus
- Química (todo)
- Ingeniería química (todo)