Experimental cardio-depressant effects of clonixin

D. Bustamante, M. Morales, T. Pelissier, H. Saavedra, H. F. Miranda, C. Paeile

Resultado de la investigación: Article

4 Citas (Scopus)

Resumen

1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

Idioma originalEnglish
Páginas (desde-hasta)605-608
Número de páginas4
PublicaciónGeneral Pharmacology
Volumen20
N.º5
DOI
EstadoPublished - 1989

Huella dactilar

Clonixin
Controlled Hypotension
Bradycardia
Muscle Contraction
Action Potentials
Calcium

ASJC Scopus subject areas

  • Pharmacology

Citar esto

Bustamante, D., Morales, M., Pelissier, T., Saavedra, H., Miranda, H. F., & Paeile, C. (1989). Experimental cardio-depressant effects of clonixin. General Pharmacology, 20(5), 605-608. https://doi.org/10.1016/0306-3623(89)90094-3
Bustamante, D. ; Morales, M. ; Pelissier, T. ; Saavedra, H. ; Miranda, H. F. ; Paeile, C. / Experimental cardio-depressant effects of clonixin. En: General Pharmacology. 1989 ; Vol. 20, N.º 5. pp. 605-608.
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Bustamante, D, Morales, M, Pelissier, T, Saavedra, H, Miranda, HF & Paeile, C 1989, 'Experimental cardio-depressant effects of clonixin', General Pharmacology, vol. 20, n.º 5, pp. 605-608. https://doi.org/10.1016/0306-3623(89)90094-3

Experimental cardio-depressant effects of clonixin. / Bustamante, D.; Morales, M.; Pelissier, T.; Saavedra, H.; Miranda, H. F.; Paeile, C.

En: General Pharmacology, Vol. 20, N.º 5, 1989, p. 605-608.

Resultado de la investigación: Article

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AU - Bustamante, D.

AU - Morales, M.

AU - Pelissier, T.

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AU - Miranda, H. F.

AU - Paeile, C.

PY - 1989

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AB - 1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

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Bustamante D, Morales M, Pelissier T, Saavedra H, Miranda HF, Paeile C. Experimental cardio-depressant effects of clonixin. General Pharmacology. 1989;20(5):605-608. https://doi.org/10.1016/0306-3623(89)90094-3