Experimental cardio-depressant effects of clonixin

D. Bustamante, M. Morales, T. Pelissier, H. Saavedra, H. F. Miranda, C. Paeile

Resultado de la investigación: Contribución a una revistaArtículo

5 Citas (Scopus)

Resumen

1. 1. The cardiovascular effects of CLX were studied. 2. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.

Idioma originalInglés
Páginas (desde-hasta)605-608
Número de páginas4
PublicaciónGeneral Pharmacology
Volumen20
N.º5
DOI
EstadoPublicada - 1989

Áreas temáticas de ASJC Scopus

  • Farmacología

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    Bustamante, D., Morales, M., Pelissier, T., Saavedra, H., Miranda, H. F., & Paeile, C. (1989). Experimental cardio-depressant effects of clonixin. General Pharmacology, 20(5), 605-608. https://doi.org/10.1016/0306-3623(89)90094-3