Exercise and prostate cancer: From basic science to clinical applications

Christian Campos, Paula Sotomayor, Daniel Jerez, Javier González, Camila B. Schmidt, Katharina Schmidt, Winfried Banzer, Alejandro S. Godoy

Resultado de la investigación: Article

  • 1 Citas

Resumen

Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment. The standard treatment for locally advanced or metastatic PCa is Androgen deprivation therapy (ADT). ADT produces diverse side effects, including loss of libido, changes in body composition (increase abdominal fat), and reduced muscle mass, and muscle tone. Analysis of numerous research publications showed that aerobic and/or resistance training improve patient's physical condition, such us, cardiorespiratory fitness, muscle strength, physical function, body composition, and fatigue. Therefore, exercise might counteract several ADT treatment-induced side effects. In addition of the aforementioned benefits, epidemiological, and in vitro studies have shown that exercise might decrease PCa development. Thus, physical activity might attenuate the risk of PCa and supervised exercise intervention might improve deleterious effects of cancer treatment, such as ADT side effects. This review article provides evidence indicating that exercise could complement, and potentiate, the current standard treatments for advanced PCa, probably by creating an unfavorable microenvironment that can negatively affect tumor development, and progression.

IdiomaEnglish
Páginas639-645
Número de páginas7
PublicaciónProstate
Volumen78
Número de edición9
DOI
EstadoAccepted/In press - 1 ene 2018

Huella dactilar

Prostatic Neoplasms
Exercise
Androgens
Therapeutics
Neoplasms
Body Composition
Libido
Muscles
Abdominal Fat
Resistance Training
Muscle Strength
Developed Countries
Fatigue
Publications
Meta-Analysis
Epidemiologic Studies
Research

Keywords

    ASJC Scopus subject areas

    • Oncology
    • Urology

    Citar esto

    Campos, C., Sotomayor, P., Jerez, D., González, J., Schmidt, C. B., Schmidt, K., ... Godoy, A. S. (Aceptado/En prensa). Exercise and prostate cancer: From basic science to clinical applications. Prostate, 78(9), 639-645. https://doi.org/10.1002/pros.23502
    Campos, Christian ; Sotomayor, Paula ; Jerez, Daniel ; González, Javier ; Schmidt, Camila B. ; Schmidt, Katharina ; Banzer, Winfried ; Godoy, Alejandro S. / Exercise and prostate cancer : From basic science to clinical applications. En: Prostate. 2018 ; Vol. 78, N.º 9. pp. 639-645.
    @article{f5745bcd75fb49ab92af96327c8c7b00,
    title = "Exercise and prostate cancer: From basic science to clinical applications",
    abstract = "Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment. The standard treatment for locally advanced or metastatic PCa is Androgen deprivation therapy (ADT). ADT produces diverse side effects, including loss of libido, changes in body composition (increase abdominal fat), and reduced muscle mass, and muscle tone. Analysis of numerous research publications showed that aerobic and/or resistance training improve patient's physical condition, such us, cardiorespiratory fitness, muscle strength, physical function, body composition, and fatigue. Therefore, exercise might counteract several ADT treatment-induced side effects. In addition of the aforementioned benefits, epidemiological, and in vitro studies have shown that exercise might decrease PCa development. Thus, physical activity might attenuate the risk of PCa and supervised exercise intervention might improve deleterious effects of cancer treatment, such as ADT side effects. This review article provides evidence indicating that exercise could complement, and potentiate, the current standard treatments for advanced PCa, probably by creating an unfavorable microenvironment that can negatively affect tumor development, and progression.",
    keywords = "Aerobic exercise, Androgen deprivation therapy, Physical activity, Resistance training",
    author = "Christian Campos and Paula Sotomayor and Daniel Jerez and Javier Gonz{\'a}lez and Schmidt, {Camila B.} and Katharina Schmidt and Winfried Banzer and Godoy, {Alejandro S.}",
    year = "2018",
    month = "1",
    day = "1",
    doi = "10.1002/pros.23502",
    language = "English",
    volume = "78",
    pages = "639--645",
    journal = "Prostate",
    issn = "0270-4137",
    publisher = "Wiley-Liss Inc.",
    number = "9",

    }

    Campos, C, Sotomayor, P, Jerez, D, González, J, Schmidt, CB, Schmidt, K, Banzer, W & Godoy, AS 2018, 'Exercise and prostate cancer: From basic science to clinical applications' Prostate, vol. 78, n.º 9, pp. 639-645. https://doi.org/10.1002/pros.23502

    Exercise and prostate cancer : From basic science to clinical applications. / Campos, Christian; Sotomayor, Paula; Jerez, Daniel; González, Javier; Schmidt, Camila B.; Schmidt, Katharina; Banzer, Winfried; Godoy, Alejandro S.

    En: Prostate, Vol. 78, N.º 9, 01.01.2018, p. 639-645.

    Resultado de la investigación: Article

    TY - JOUR

    T1 - Exercise and prostate cancer

    T2 - Prostate

    AU - Campos, Christian

    AU - Sotomayor, Paula

    AU - Jerez, Daniel

    AU - González, Javier

    AU - Schmidt, Camila B.

    AU - Schmidt, Katharina

    AU - Banzer, Winfried

    AU - Godoy, Alejandro S.

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment. The standard treatment for locally advanced or metastatic PCa is Androgen deprivation therapy (ADT). ADT produces diverse side effects, including loss of libido, changes in body composition (increase abdominal fat), and reduced muscle mass, and muscle tone. Analysis of numerous research publications showed that aerobic and/or resistance training improve patient's physical condition, such us, cardiorespiratory fitness, muscle strength, physical function, body composition, and fatigue. Therefore, exercise might counteract several ADT treatment-induced side effects. In addition of the aforementioned benefits, epidemiological, and in vitro studies have shown that exercise might decrease PCa development. Thus, physical activity might attenuate the risk of PCa and supervised exercise intervention might improve deleterious effects of cancer treatment, such as ADT side effects. This review article provides evidence indicating that exercise could complement, and potentiate, the current standard treatments for advanced PCa, probably by creating an unfavorable microenvironment that can negatively affect tumor development, and progression.

    AB - Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment. The standard treatment for locally advanced or metastatic PCa is Androgen deprivation therapy (ADT). ADT produces diverse side effects, including loss of libido, changes in body composition (increase abdominal fat), and reduced muscle mass, and muscle tone. Analysis of numerous research publications showed that aerobic and/or resistance training improve patient's physical condition, such us, cardiorespiratory fitness, muscle strength, physical function, body composition, and fatigue. Therefore, exercise might counteract several ADT treatment-induced side effects. In addition of the aforementioned benefits, epidemiological, and in vitro studies have shown that exercise might decrease PCa development. Thus, physical activity might attenuate the risk of PCa and supervised exercise intervention might improve deleterious effects of cancer treatment, such as ADT side effects. This review article provides evidence indicating that exercise could complement, and potentiate, the current standard treatments for advanced PCa, probably by creating an unfavorable microenvironment that can negatively affect tumor development, and progression.

    KW - Aerobic exercise

    KW - Androgen deprivation therapy

    KW - Physical activity

    KW - Resistance training

    UR - http://www.scopus.com/inward/record.url?scp=85044773584&partnerID=8YFLogxK

    U2 - 10.1002/pros.23502

    DO - 10.1002/pros.23502

    M3 - Article

    VL - 78

    SP - 639

    EP - 645

    JO - Prostate

    JF - Prostate

    SN - 0270-4137

    IS - 9

    ER -