Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens

H. Miranda, F. Huidobro, J. Pablo Huidobro-Toro

Resultado de la investigación: Article

39 Citas (Scopus)

Resumen

The application of morphine or surrogates to the isolated rat vas deferens maintained at 37° C in Tyrode solution, produced an increase in the electrically induced muscular twitch. In contrast, leucine enkephalin or D-alanine2methionine enkephalinamide produced a dose-dependent inhibition of the muscular twitch. The effect of morphine and derivatives was not antagonized by naloxone, but the depression caused by the opiate pentapeptides or β-Endorphin was readily antagonized and reversed by naloxone. Tolerance developed to the in vitro effect of morphine; vasa deferentia obtained from tolerant-dependent rats were about six times less sensitive to the effect of morphine and about five times less sensitive to the depression caused by leucine enkephalin as compared to their respective paired, placebo implanted control rats.

Idioma originalEnglish
Páginas (desde-hasta)1511-1518
Número de páginas8
PublicaciónLife Sciences
Volumen24
N.º16
DOI
EstadoPublished - 16 abr 1979

Huella dactilar

Vas Deferens
Naloxone
Alkaloids
Morphine
Leucine Enkephalin
Rats
Opiate Alkaloids
Morphine Derivatives
Rat control
Endorphins
Placebos

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Citar esto

Miranda, H. ; Huidobro, F. ; Huidobro-Toro, J. Pablo. / Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens. En: Life Sciences. 1979 ; Vol. 24, N.º 16. pp. 1511-1518.
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Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens. / Miranda, H.; Huidobro, F.; Huidobro-Toro, J. Pablo.

En: Life Sciences, Vol. 24, N.º 16, 16.04.1979, p. 1511-1518.

Resultado de la investigación: Article

TY - JOUR

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AU - Huidobro-Toro, J. Pablo

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AB - The application of morphine or surrogates to the isolated rat vas deferens maintained at 37° C in Tyrode solution, produced an increase in the electrically induced muscular twitch. In contrast, leucine enkephalin or D-alanine2methionine enkephalinamide produced a dose-dependent inhibition of the muscular twitch. The effect of morphine and derivatives was not antagonized by naloxone, but the depression caused by the opiate pentapeptides or β-Endorphin was readily antagonized and reversed by naloxone. Tolerance developed to the in vitro effect of morphine; vasa deferentia obtained from tolerant-dependent rats were about six times less sensitive to the effect of morphine and about five times less sensitive to the depression caused by leucine enkephalin as compared to their respective paired, placebo implanted control rats.

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