Resumen
Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.
Idioma original | Spanish |
---|---|
Páginas (desde-hasta) | 84-96 |
Número de páginas | 13 |
Publicación | Revista Chilena de Infectologia |
Volumen | 32 |
N.º | 1 |
Estado | Published - 1 ene 2015 |
Publicado de forma externa | Sí |
Huella dactilar
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases
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Evasión de la respuesta inmune por virus herpes simplex. / Retamal-Díaz, Angello R.; Suazo, Paula A.; Garrido, Ignacio; Kalergis, Alexis M.; González, Pablo A.
En: Revista Chilena de Infectologia, Vol. 32, N.º 1, 01.01.2015, p. 84-96.Resultado de la investigación: Article
TY - JOUR
T1 - Evasión de la respuesta inmune por virus herpes simplex
AU - Retamal-Díaz, Angello R.
AU - Suazo, Paula A.
AU - Garrido, Ignacio
AU - Kalergis, Alexis M.
AU - González, Pablo A.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.
AB - Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.
KW - Adaptive immune evasion
KW - Genital infection
KW - Innate immune evasion
KW - Latency
KW - Reactivation
UR - http://www.scopus.com/inward/record.url?scp=84926197961&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84926197961
VL - 32
SP - 84
EP - 96
JO - Revista Chilena de Infectologia
JF - Revista Chilena de Infectologia
SN - 0716-1018
IS - 1
ER -