Evasión de la respuesta inmune por virus herpes simplex

Angello R. Retamal-Díaz, Paula A. Suazo, Ignacio Garrido, Alexis M. Kalergis, Pablo A. González

Resultado de la investigación: Article

1 Cita (Scopus)

Resumen

Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.

Idioma originalSpanish
Páginas (desde-hasta)84-96
Número de páginas13
PublicaciónRevista Chilena de Infectologia
Volumen32
N.º1
EstadoPublished - 1 ene 2015
Publicado de forma externa

Huella dactilar

Immune Evasion
Simplexvirus
Virus Diseases
Active Immunotherapy
Spinal Ganglia
Adaptive Immunity
Infection
Innate Immunity
Immunity
Vaccines
Viruses
Neurons
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Citar esto

Retamal-Díaz, A. R., Suazo, P. A., Garrido, I., Kalergis, A. M., & González, P. A. (2015). Evasión de la respuesta inmune por virus herpes simplex. Revista Chilena de Infectologia, 32(1), 84-96.
Retamal-Díaz, Angello R. ; Suazo, Paula A. ; Garrido, Ignacio ; Kalergis, Alexis M. ; González, Pablo A. / Evasión de la respuesta inmune por virus herpes simplex. En: Revista Chilena de Infectologia. 2015 ; Vol. 32, N.º 1. pp. 84-96.
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Retamal-Díaz, AR, Suazo, PA, Garrido, I, Kalergis, AM & González, PA 2015, 'Evasión de la respuesta inmune por virus herpes simplex', Revista Chilena de Infectologia, vol. 32, n.º 1, pp. 84-96.

Evasión de la respuesta inmune por virus herpes simplex. / Retamal-Díaz, Angello R.; Suazo, Paula A.; Garrido, Ignacio; Kalergis, Alexis M.; González, Pablo A.

En: Revista Chilena de Infectologia, Vol. 32, N.º 1, 01.01.2015, p. 84-96.

Resultado de la investigación: Article

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AU - Garrido, Ignacio

AU - Kalergis, Alexis M.

AU - González, Pablo A.

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AB - Herpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination.

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KW - Genital infection

KW - Innate immune evasion

KW - Latency

KW - Reactivation

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Retamal-Díaz AR, Suazo PA, Garrido I, Kalergis AM, González PA. Evasión de la respuesta inmune por virus herpes simplex. Revista Chilena de Infectologia. 2015 ene 1;32(1):84-96.