Estrogen and progesterone receptors in the oviduct during egg transport in cyclic and pregnant rats.

B. Fuentealba, M. Nieto, H. B. Croxatto

Resultado de la investigación: Contribución a una revistaArtículo

13 Citas (Scopus)

Resumen

We investigated the temporal relationships between ovum transport and changes in the concentration of nuclear steroid receptors in the oviduct of cyclic and pregnant rats. A lack of parallelism between estrogen and progesterone fluctuations in plasma and their respective nuclear receptor concentrations in the oviduct predominated during egg transport. In pregnant animals, oviductal egg transport took 24 h longer than in nonpregnant animals. In both conditions, transport was initiated while the action of estrogen and progesterone on the oviduct--measured as nuclear receptor accumulation--was decreasing. Three or four days later, depending on whether the animal was pregnant, the eggs entered the uterus shortly after an increase in the nuclear receptor accumulation of both hormones. Treatment with RU486, a progesterone receptor-blocking agent known to cause premature arrival of eggs in the uterus, advanced estrogen receptor accumulation in the oviduct of pregnant rats. These data suggest that the arrival of eggs in the uterus is timed by a transitory increase in nuclear estrogen receptor in the oviduct that does not necessarily reflect a similar change of circulating estradiol. Moreover, in pregnant rats, the onset of this estrogenic action is delayed by a progesterone receptor-mediated effect that hinders nuclear estrogen receptor accumulation.

Idioma originalInglés
Páginas (desde-hasta)751-757
Número de páginas7
PublicaciónBiology of Reproduction
Volumen39
N.º4
EstadoPublicada - nov 1988

Áreas temáticas de ASJC Scopus

  • Biología celular
  • Biología del desarrollo
  • Embriología
  • Medicina (todo)

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