TY - JOUR
T1 - Endothelial dysfunction in pregnancy metabolic disorders
AU - Echeverria, Cesar
AU - Eltit, Felipe
AU - Santibanez, Juan F.
AU - Gatica, Sebastian
AU - Cabello-Verrugio, Claudio
AU - Simon, Felipe
N1 - Funding Information:
This work was supported by research grants from Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt 1161288 (FS), 21171566 (SG), 11170840 (CE), and 1161646 (CCV). Millennium Institute on Immunology and Immunotherapy P09-016-F (FS, CCV). Comisión Nacional de Investigación Científica y Tecnológica – CONICYT 21171566 (SG). Ministry of Education, Science and Technological Development of the Republic of Serbia grants 175024 and 175053 (JFS). Programa de Cooperación Científica ECOS-CONICYT C16S02 (CCV). BASAL Grant CEDENNA FB0807 (CCV).
Funding Information:
This work was supported by research grants from Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt 1161288 (FS), 21171566 (SG), 11170840 (CE), and 1161646 (CCV). Millennium Institute on Immunology and Immunotherapy P09-016-F (FS, CCV). Comisión Nacional de Investigación Científica y Tecnológica – CONICYT 21171566 (SG). Ministry of Education, Science and Technological Development of the Republic of Serbia grants 175024 and 175053 (JFS). Programa de Cooperación Científica ECOS-CONICYT C16S02 (CCV). BASAL Grant CEDENNA FB0807 (CCV).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.
AB - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.
KW - Endothelial dysfunction
KW - Metabolic disorders
KW - Pregnancy
KW - Receptors
KW - Transporters
UR - http://www.scopus.com/inward/record.url?scp=85062042871&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2019.02.009
DO - 10.1016/j.bbadis.2019.02.009
M3 - Review article
AN - SCOPUS:85062042871
SN - 0925-4439
VL - 1866
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 2
M1 - 165414
ER -
