Endothelial dysfunction in pregnancy metabolic disorders

Cesar Echeverria, Felipe Eltit, Juan F. Santibanez, Sebastian Gatica, Claudio Cabello-Verrugio, Felipe Simon

Resultado de la investigación: Review article

Resumen

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.

Huella dactilar

Pregnancy
Gestational Diabetes
Vascular Endothelium
Hyperlipidemias
Endothelium
Endothelial Cells
Obesity

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Citar esto

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title = "Endothelial dysfunction in pregnancy metabolic disorders",
abstract = "In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.",
keywords = "Endothelial dysfunction, Metabolic disorders, Pregnancy, Receptors, Transporters",
author = "Cesar Echeverria and Felipe Eltit and Santibanez, {Juan F.} and Sebastian Gatica and Claudio Cabello-Verrugio and Felipe Simon",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.bbadis.2019.02.009",
language = "English",
journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier",

}

Endothelial dysfunction in pregnancy metabolic disorders. / Echeverria, Cesar; Eltit, Felipe; Santibanez, Juan F.; Gatica, Sebastian; Cabello-Verrugio, Claudio; Simon, Felipe.

En: Biochimica et Biophysica Acta - Molecular Basis of Disease, 01.01.2019.

Resultado de la investigación: Review article

TY - JOUR

T1 - Endothelial dysfunction in pregnancy metabolic disorders

AU - Echeverria, Cesar

AU - Eltit, Felipe

AU - Santibanez, Juan F.

AU - Gatica, Sebastian

AU - Cabello-Verrugio, Claudio

AU - Simon, Felipe

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.

AB - In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.

KW - Endothelial dysfunction

KW - Metabolic disorders

KW - Pregnancy

KW - Receptors

KW - Transporters

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U2 - 10.1016/j.bbadis.2019.02.009

DO - 10.1016/j.bbadis.2019.02.009

M3 - Review article

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

SN - 0925-4439

ER -