Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women

G. Noé, R. Sitruk-Ware, F. Zegers-Hochschild, B. Variano, J. C. Montero, P. Arriagada, A. Li, F. Z. Stanczyk, J. C. Felix, D. R. Mishell, H. B. Croxatto

Resultado de la investigación: Article

5 Citas (Scopus)

Resumen

AimThe type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefitrisk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal women. MethodForty-four postmenopausal women participated in a randomized, double-blind, dose-finding study evaluating two hormonal treatments, combining 50μg/day of estradiol delivered by transdermal patches and either 0.5-g or 1-g progesterone vaginal rings (PVR) given for 12 weeks. The effect on the endometrium was assessed by histology and the detection of the proliferative marker Ki-67. We also measured the serum concentration of estradiol and progesterone, the tissue concentration of progesterone and the immunolocalization of estradiol and progesterone receptors in the endometrium. ResultsEndometrial thickness was increased after both treatments, although endometrial histology appeared atrophic in most biopsies. A circulating doseresponse of serum progesterone levels was observed from the first to the 12th week of PVR use. In the high-progesterone-dose group, the scarce presence of Ki-67 and hormone receptors reflected the predominant action of progesterone in endometrial glands and stroma, in parallel with a lower tissue concentration of progesterone in this group. ConclusionThe PVR appears to be a promising method of administering natural progesterone to postmenopausal women treated with estrogen. Estradiol levels corrected the menopausal symptoms, as expected, and the presence of atrophic endometrium in the majority of women indicated that both doses of progesterone oppose the stimulatory estradiol effects, although the percentage of proliferative tissue was not negligible in both groups.

Idioma originalEnglish
Páginas (desde-hasta)433-441
Número de páginas9
PublicaciónClimacteric
Volumen13
N.º5
DOI
EstadoPublished - 1 oct 2010

Huella dactilar

Female Contraceptive Devices
Progesterone
Estrogens
Estradiol
Endometrium
Histology
Hormones
Transdermal Patch
Estradiol Receptors
Progestins
Progesterone Receptors
Serum

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Citar esto

Noé, G., Sitruk-Ware, R., Zegers-Hochschild, F., Variano, B., Montero, J. C., Arriagada, P., ... Croxatto, H. B. (2010). Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women. Climacteric, 13(5), 433-441. https://doi.org/10.3109/13697137.2010.492060
Noé, G. ; Sitruk-Ware, R. ; Zegers-Hochschild, F. ; Variano, B. ; Montero, J. C. ; Arriagada, P. ; Li, A. ; Stanczyk, F. Z. ; Felix, J. C. ; Mishell, D. R. ; Croxatto, H. B. / Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women. En: Climacteric. 2010 ; Vol. 13, N.º 5. pp. 433-441.
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abstract = "AimThe type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefitrisk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal women. MethodForty-four postmenopausal women participated in a randomized, double-blind, dose-finding study evaluating two hormonal treatments, combining 50μg/day of estradiol delivered by transdermal patches and either 0.5-g or 1-g progesterone vaginal rings (PVR) given for 12 weeks. The effect on the endometrium was assessed by histology and the detection of the proliferative marker Ki-67. We also measured the serum concentration of estradiol and progesterone, the tissue concentration of progesterone and the immunolocalization of estradiol and progesterone receptors in the endometrium. ResultsEndometrial thickness was increased after both treatments, although endometrial histology appeared atrophic in most biopsies. A circulating doseresponse of serum progesterone levels was observed from the first to the 12th week of PVR use. In the high-progesterone-dose group, the scarce presence of Ki-67 and hormone receptors reflected the predominant action of progesterone in endometrial glands and stroma, in parallel with a lower tissue concentration of progesterone in this group. ConclusionThe PVR appears to be a promising method of administering natural progesterone to postmenopausal women treated with estrogen. Estradiol levels corrected the menopausal symptoms, as expected, and the presence of atrophic endometrium in the majority of women indicated that both doses of progesterone oppose the stimulatory estradiol effects, although the percentage of proliferative tissue was not negligible in both groups.",
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Noé, G, Sitruk-Ware, R, Zegers-Hochschild, F, Variano, B, Montero, JC, Arriagada, P, Li, A, Stanczyk, FZ, Felix, JC, Mishell, DR & Croxatto, HB 2010, 'Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women', Climacteric, vol. 13, n.º 5, pp. 433-441. https://doi.org/10.3109/13697137.2010.492060

Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women. / Noé, G.; Sitruk-Ware, R.; Zegers-Hochschild, F.; Variano, B.; Montero, J. C.; Arriagada, P.; Li, A.; Stanczyk, F. Z.; Felix, J. C.; Mishell, D. R.; Croxatto, H. B.

En: Climacteric, Vol. 13, N.º 5, 01.10.2010, p. 433-441.

Resultado de la investigación: Article

TY - JOUR

T1 - Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women

AU - Noé, G.

AU - Sitruk-Ware, R.

AU - Zegers-Hochschild, F.

AU - Variano, B.

AU - Montero, J. C.

AU - Arriagada, P.

AU - Li, A.

AU - Stanczyk, F. Z.

AU - Felix, J. C.

AU - Mishell, D. R.

AU - Croxatto, H. B.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - AimThe type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefitrisk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal women. MethodForty-four postmenopausal women participated in a randomized, double-blind, dose-finding study evaluating two hormonal treatments, combining 50μg/day of estradiol delivered by transdermal patches and either 0.5-g or 1-g progesterone vaginal rings (PVR) given for 12 weeks. The effect on the endometrium was assessed by histology and the detection of the proliferative marker Ki-67. We also measured the serum concentration of estradiol and progesterone, the tissue concentration of progesterone and the immunolocalization of estradiol and progesterone receptors in the endometrium. ResultsEndometrial thickness was increased after both treatments, although endometrial histology appeared atrophic in most biopsies. A circulating doseresponse of serum progesterone levels was observed from the first to the 12th week of PVR use. In the high-progesterone-dose group, the scarce presence of Ki-67 and hormone receptors reflected the predominant action of progesterone in endometrial glands and stroma, in parallel with a lower tissue concentration of progesterone in this group. ConclusionThe PVR appears to be a promising method of administering natural progesterone to postmenopausal women treated with estrogen. Estradiol levels corrected the menopausal symptoms, as expected, and the presence of atrophic endometrium in the majority of women indicated that both doses of progesterone oppose the stimulatory estradiol effects, although the percentage of proliferative tissue was not negligible in both groups.

AB - AimThe type of estrogen and progestin as well as their doses, route and regimens of administration may each affect the benefitrisk profile of postmenopausal hormone therapy. The aim of this study was to evaluate the endometrial effect of progesterone released continuously from a vaginal ring, combined with transdermal estradiol in postmenopausal women. MethodForty-four postmenopausal women participated in a randomized, double-blind, dose-finding study evaluating two hormonal treatments, combining 50μg/day of estradiol delivered by transdermal patches and either 0.5-g or 1-g progesterone vaginal rings (PVR) given for 12 weeks. The effect on the endometrium was assessed by histology and the detection of the proliferative marker Ki-67. We also measured the serum concentration of estradiol and progesterone, the tissue concentration of progesterone and the immunolocalization of estradiol and progesterone receptors in the endometrium. ResultsEndometrial thickness was increased after both treatments, although endometrial histology appeared atrophic in most biopsies. A circulating doseresponse of serum progesterone levels was observed from the first to the 12th week of PVR use. In the high-progesterone-dose group, the scarce presence of Ki-67 and hormone receptors reflected the predominant action of progesterone in endometrial glands and stroma, in parallel with a lower tissue concentration of progesterone in this group. ConclusionThe PVR appears to be a promising method of administering natural progesterone to postmenopausal women treated with estrogen. Estradiol levels corrected the menopausal symptoms, as expected, and the presence of atrophic endometrium in the majority of women indicated that both doses of progesterone oppose the stimulatory estradiol effects, although the percentage of proliferative tissue was not negligible in both groups.

KW - endometrium

KW - Postmenopausal therapy

KW - progesterone

KW - vaginal rings

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U2 - 10.3109/13697137.2010.492060

DO - 10.3109/13697137.2010.492060

M3 - Article

C2 - 20642326

AN - SCOPUS:77956155402

VL - 13

SP - 433

EP - 441

JO - Climacteric

JF - Climacteric

SN - 1369-7137

IS - 5

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Noé G, Sitruk-Ware R, Zegers-Hochschild F, Variano B, Montero JC, Arriagada P y otros. Endometrial effect of progesterone delivered by vaginal rings in estrogen-treated postmenopausal women. Climacteric. 2010 oct 1;13(5):433-441. https://doi.org/10.3109/13697137.2010.492060