Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties

Nicolás Palacios-Prado, Paola A. Soto, Ximena López, Eun Ju Choi, Valeria Marquez-Miranda, Maximiliano Rojas, Yorley Duarte, Jinu Lee, Fernando D. González-Nilo, Juan C. Sáez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

SignificancePannexin1 is a glycoprotein that has been shown to form functional plasma membrane channels and mediate many cellular signaling pathways. However, the formation and function of pannexin1-based intercellular cell-cell channels in mammalian cells and vertebrate tissue is a question of substantial debate. This work provides robust electrophysiological evidence to demonstrate that endogenously expressed human pannexin1 forms cell-cell channels and lays the groundwork for studying a potential new type of electrical synapses between many mammalian cell types that endogenously express pannexin1.

Idioma originalInglés
Páginas (desde-hasta)e2202104119
PublicaciónProceedings of the National Academy of Sciences of the United States of America
Volumen119
N.º18
DOI
EstadoPublicada - 3 may. 2022

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